FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1481700503> ?p ?o ?g. }

• W1481700503 endingPage "797" @default.
• W1481700503 startingPage "786" @default.
• W1481700503 abstract "Few studies have investigated whether genetic abnormalities predispose individuals to heavy betel quid (BQ) use. One of the major ingredients of BQ, arecoline, is known to affect the expression of monoamine oxidase A (MAO-A). We investigated the extent to which arecoline inhibits MAO-A expression and the role of MAO-A polymorphisms in BQ use in Taiwanese aborigines. Cytotoxicity assays, microarrays and quantitative reverse transcriptase-polymerase chain reaction were used to examine the effects of arecoline and areca nut extract (ANE) on cell viability and MAO-A expression in neuroblastoma SH-SY5Y cells. After identifying the effective concentrations of arecoline and ANE in vitro, we examined the in vivo effects of these compounds using a rat model system. Our results indicate that arecoline and ANE inhibit MAO-A expression both in vitro and in vivo. In addition, we examined the correlation between plasma MAO-A activity and cumulative exposure to BQ in humans. We recruited 1307 aborigines from a large-scale community-based survey to determine whether MAO-A variants were associated with high BQ use and a preference for use with smoking or alcohol and whether gender bias existed. MAO-A expression was significantly downregulated by arecoline and ANE at 100–200 µg/ml and in rat whole brains on days 30 and 45. MAO-A activity levels in human plasma were positively correlated with the extent of BQ exposure, and individuals with at-risk alleles exhibited lower activity, although this result did not reach statistical significance. We found two single nucleotide polymorphism (SNPs) in aboriginal males [rs2283725, odds ratio (OR) = 2.04; rs5953210, OR = 2.03] and females (rs2283725, OR = 1.54; rs5953210, OR = 1.59) that were associated with heavy BQ use. Those individuals carrying at-risk alleles who drank alcohol were twice as likely to be heavy BQ users. However, the effects of these SNPs on BQ use were significant even after controlling for alcohol use. Our results suggest that two specific loci may confer a susceptibility to BQ abuse and affect MAO-A enzymatic activity." @default.
• W1481700503 created "2016-06-24" @default.
• W1481700503 creator A5030585729 @default.
• W1481700503 creator A5033235930 @default.
• W1481700503 creator A5038056354 @default.
• W1481700503 creator A5040509839 @default.
• W1481700503 creator A5047690281 @default.
• W1481700503 creator A5058589474 @default.
• W1481700503 creator A5067150020 @default.
• W1481700503 creator A5068758998 @default.
• W1481700503 creator A5072563983 @default.
• W1481700503 creator A5082581515 @default.
• W1481700503 creator A5083460724 @default.
• W1481700503 creator A5091602628 @default.
• W1481700503 date "2011-04-26" @default.
• W1481700503 modified "2023-10-18" @default.
• W1481700503 title "Monoamine oxidase A variants are associated with heavy betel quid use" @default.
• W1481700503 cites W110720742 @default.
• W1481700503 cites W1970604874 @default.
• W1481700503 cites W1981293590 @default.
• W1481700503 cites W1982646240 @default.
• W1481700503 cites W1982930764 @default.
• W1481700503 cites W1983106271 @default.
• W1481700503 cites W1998360317 @default.
• W1481700503 cites W2003486247 @default.
• W1481700503 cites W2003513078 @default.
• W1481700503 cites W2004370204 @default.
• W1481700503 cites W2006887915 @default.
• W1481700503 cites W2016730013 @default.
• W1481700503 cites W2019356428 @default.
• W1481700503 cites W2024571738 @default.
• W1481700503 cites W2030692426 @default.
• W1481700503 cites W2040661537 @default.
• W1481700503 cites W2041654859 @default.
• W1481700503 cites W2043475588 @default.
• W1481700503 cites W2043479151 @default.
• W1481700503 cites W2054930477 @default.
• W1481700503 cites W2060660311 @default.
• W1481700503 cites W2061762326 @default.
• W1481700503 cites W2065689992 @default.
• W1481700503 cites W2077667371 @default.
• W1481700503 cites W2083684201 @default.
• W1481700503 cites W2087349257 @default.
• W1481700503 cites W2093292871 @default.
• W1481700503 cites W2094700723 @default.
• W1481700503 cites W2106322351 @default.
• W1481700503 cites W2108980184 @default.
• W1481700503 cites W2112504770 @default.
• W1481700503 cites W2126582263 @default.
• W1481700503 cites W2152884711 @default.
• W1481700503 cites W2153455171 @default.
• W1481700503 cites W2159788418 @default.
• W1481700503 cites W2160964291 @default.
• W1481700503 cites W2162766713 @default.
• W1481700503 cites W2163309905 @default.
• W1481700503 cites W2171662976 @default.
• W1481700503 cites W2207684096 @default.
• W1481700503 cites W2412403533 @default.
• W1481700503 cites W4235956464 @default.
• W1481700503 doi "https://doi.org/10.1111/j.1369-1600.2011.00331.x" @default.
• W1481700503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21521428" @default.
• W1481700503 hasPublicationYear "2011" @default.
• W1481700503 type Work @default.
• W1481700503 sameAs 1481700503 @default.
• W1481700503 citedByCount "20" @default.
• W1481700503 countsByYear W14817005032012 @default.
• W1481700503 countsByYear W14817005032014 @default.
• W1481700503 countsByYear W14817005032016 @default.
• W1481700503 countsByYear W14817005032017 @default.
• W1481700503 countsByYear W14817005032019 @default.
• W1481700503 countsByYear W14817005032020 @default.
• W1481700503 countsByYear W14817005032021 @default.
• W1481700503 countsByYear W14817005032022 @default.
• W1481700503 countsByYear W14817005032023 @default.
• W1481700503 crossrefType "journal-article" @default.
• W1481700503 hasAuthorship W1481700503A5030585729 @default.
• W1481700503 hasAuthorship W1481700503A5033235930 @default.
• W1481700503 hasAuthorship W1481700503A5038056354 @default.
• W1481700503 hasAuthorship W1481700503A5040509839 @default.
• W1481700503 hasAuthorship W1481700503A5047690281 @default.
• W1481700503 hasAuthorship W1481700503A5058589474 @default.
• W1481700503 hasAuthorship W1481700503A5067150020 @default.
• W1481700503 hasAuthorship W1481700503A5068758998 @default.
• W1481700503 hasAuthorship W1481700503A5072563983 @default.
• W1481700503 hasAuthorship W1481700503A5082581515 @default.
• W1481700503 hasAuthorship W1481700503A5083460724 @default.
• W1481700503 hasAuthorship W1481700503A5091602628 @default.
• W1481700503 hasConcept C104317684 @default.
• W1481700503 hasConcept C114461151 @default.
• W1481700503 hasConcept C126322002 @default.
• W1481700503 hasConcept C127413603 @default.
• W1481700503 hasConcept C135763542 @default.
• W1481700503 hasConcept C153209595 @default.
• W1481700503 hasConcept C153911025 @default.
• W1481700503 hasConcept C170493617 @default.
• W1481700503 hasConcept C181199279 @default.
• W1481700503 hasConcept C185592680 @default.
• W1481700503 hasConcept C206391251 @default.

• next