FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1481716780> ?p ?o ?g. }

• W1481716780 abstract "Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis, which is transmitted through inhalation of aerosolized droplets. TB mainly attacks the lungs, but can also affect other parts of the body. TB is highly contagious during the active stage of the disease and can infect an individual through inhalation of as few as 10 Mycobacterium tuberculosis (MTB) bacteria. After inhalation, these bacteria are mainly captured by the alveolar macrophages, but they can evade the host immune system and remain in the dormant stage for a long period of time, at which point they can reactivate to a virulent form under immune-compromised conditions of the host. This is possible because M. tuberculosis can persist in slow growing as well as in fast growing stages which makes treatment challenging. Almost all of the antibiotics that can be used to treat TB work when the bacteria are actively dividing. In the intensive phase of TB treatment, the antibiotics mainly kill rapidly growing bacteria, which causes rapid sputum conversion, and the eradication of clinical symptoms. However, in order to kill the persistent or slow growing strains of MTB, the continuation phase of the treatment is essential. TB can be treated effectively by using first line drugs (FLD) isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), ethambutol (EMB) and streptomycin (SM). However, this first line therapy often fails to cure TB for several reasons. Relapse and the spread of the disease contribute to the emergence of drug resistant bacteria. The emergence of multidrug resistant TB (MDR-TB), i.e. which is resistant to at least isoniazid (INH) and rifampicin (RIF), is of great concern, because it requires the use of second-line drugs that are difficult to procure and are much more toxic and expensive than FLDs [1]. Therefore, the detection and treatment of drug susceptible or single drug resistant TB is an important strategy for preventing the emergence of MDR-TB [2]. M. tuberculosis strains with extensively drug resistant-TB (XDR-TB), that is resistant to either isoniazid or rifampicin (like MDR tuberculosis), any fluoroquinolone, and at least one of three second-line antituberculosis injectable drugs—i.e., capreomycin, kanamy‐ cin, and amikacin have also been reported [3]." @default.
• W1481716780 created "2016-06-24" @default.
• W1481716780 creator A5065379562 @default.
• W1481716780 creator A5072640565 @default.
• W1481716780 date "2013-03-20" @default.
• W1481716780 modified "2023-10-16" @default.
• W1481716780 title "First– and Second–Line Drugs and Drug Resistance" @default.
• W1481716780 cites W1213349558 @default.
• W1481716780 cites W1219937251 @default.
• W1481716780 cites W12336293 @default.
• W1481716780 cites W128341503 @default.
• W1481716780 cites W1513899899 @default.
• W1481716780 cites W1516665537 @default.
• W1481716780 cites W1568741842 @default.
• W1481716780 cites W1579095159 @default.
• W1481716780 cites W1587141131 @default.
• W1481716780 cites W1798947166 @default.
• W1481716780 cites W1805880101 @default.
• W1481716780 cites W1880202664 @default.
• W1481716780 cites W1900644743 @default.
• W1481716780 cites W1966126698 @default.
• W1481716780 cites W1966719805 @default.
• W1481716780 cites W1973456026 @default.
• W1481716780 cites W1977335789 @default.
• W1481716780 cites W1984247669 @default.
• W1481716780 cites W1995016187 @default.
• W1481716780 cites W2002991152 @default.
• W1481716780 cites W2004552934 @default.
• W1481716780 cites W2004753123 @default.
• W1481716780 cites W2010731297 @default.
• W1481716780 cites W2011128355 @default.
• W1481716780 cites W2013755313 @default.
• W1481716780 cites W2016620483 @default.
• W1481716780 cites W2025206827 @default.
• W1481716780 cites W2039733501 @default.
• W1481716780 cites W2043226567 @default.
• W1481716780 cites W2046417607 @default.
• W1481716780 cites W2048238824 @default.
• W1481716780 cites W2052965405 @default.
• W1481716780 cites W2056250732 @default.
• W1481716780 cites W2058925610 @default.
• W1481716780 cites W2065130119 @default.
• W1481716780 cites W2075000963 @default.
• W1481716780 cites W2089154924 @default.
• W1481716780 cites W2098335911 @default.
• W1481716780 cites W2099109129 @default.
• W1481716780 cites W2100197432 @default.
• W1481716780 cites W2100826766 @default.
• W1481716780 cites W2103230556 @default.
• W1481716780 cites W2107861076 @default.
• W1481716780 cites W2108206593 @default.
• W1481716780 cites W2109751189 @default.
• W1481716780 cites W2110747943 @default.
• W1481716780 cites W2119472707 @default.
• W1481716780 cites W2119603196 @default.
• W1481716780 cites W2121234754 @default.
• W1481716780 cites W2121649640 @default.
• W1481716780 cites W2122261512 @default.
• W1481716780 cites W2124243126 @default.
• W1481716780 cites W2127195760 @default.
• W1481716780 cites W2129759335 @default.
• W1481716780 cites W2130141864 @default.
• W1481716780 cites W2130263042 @default.
• W1481716780 cites W2130610060 @default.
• W1481716780 cites W2131675475 @default.
• W1481716780 cites W2132966340 @default.
• W1481716780 cites W2135027892 @default.
• W1481716780 cites W2136380288 @default.
• W1481716780 cites W2136416176 @default.
• W1481716780 cites W2137502223 @default.
• W1481716780 cites W2140509482 @default.
• W1481716780 cites W2144651829 @default.
• W1481716780 cites W2146529215 @default.
• W1481716780 cites W2148922378 @default.
• W1481716780 cites W2150700849 @default.
• W1481716780 cites W2153599083 @default.
• W1481716780 cites W2153770707 @default.
• W1481716780 cites W2154718868 @default.
• W1481716780 cites W2155766042 @default.
• W1481716780 cites W2159500985 @default.
• W1481716780 cites W2161329013 @default.
• W1481716780 cites W2164087631 @default.
• W1481716780 cites W2166566986 @default.
• W1481716780 cites W2168525492 @default.
• W1481716780 cites W2171541901 @default.
• W1481716780 cites W2215479577 @default.
• W1481716780 cites W2239829266 @default.
• W1481716780 cites W2312680562 @default.
• W1481716780 cites W2312868758 @default.
• W1481716780 cites W2318653171 @default.
• W1481716780 cites W2338591221 @default.
• W1481716780 cites W2414200852 @default.
• W1481716780 cites W3145650347 @default.
• W1481716780 cites W66654475 @default.
• W1481716780 cites W1494220503 @default.
• W1481716780 cites W2184177170 @default.
• W1481716780 cites W2400958904 @default.
• W1481716780 doi "https://doi.org/10.5772/54960" @default.
• W1481716780 hasPublicationYear "2013" @default.
• W1481716780 type Work @default.

• next