Matches in SemOpenAlex for { <https://semopenalex.org/work/W1482094025> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1482094025 endingPage "1029" @default.
- W1482094025 startingPage "1028" @default.
- W1482094025 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064381 A characteristic of prostatic epithelia that is retained during the development and progression of prostate cancer is the secretion of prostate specific antigen (PSA). This property has been exploited for diagnostic purposes. The detection of PSA in serum is a valuable tool for disease diagnosis, the monitoring of progression, and response to therapy. PSA is a serine protease produced principally by men in the prostate and is under the transcriptional regulation of the androgen receptor. It is secreted by the luminal epithelia of the prostate gland and, when mixed with seminal fluid during ejaculation, cleaves structural proteins such as the seminogelins, leading to seminal liquefaction. While much is written about the utility of PSA as a disease marker, relatively little is reported on the role the protein plays in fertility or prostate cancer pathophysiology, where cancerous tissue continues to produce high levels of active enzyme. We sought generate inhibitors of PSA’s enzymatic activity for use in answering some of the fundamental questions regarding this protein. Here, we report on the design and generation of several PSA inhibitors including beta lactam serine protease inhibitors as the template for development and modeling of the enzyme’s active site. These inhibitors display varied activity profiles against PSA and other serine proteases, with functions that affect the viability of PSA-expressing cells. These activities are consistent with what was predicted by our modeling strategy. These initial compounds provide a promising starting point for the development PSA inhibitors with high potency and selectivity for its target. These may have utility in basic and preclinical studies, and eventually the clinic." @default.
- W1482094025 created "2016-06-24" @default.
- W1482094025 creator A5001771354 @default.
- W1482094025 creator A5010893381 @default.
- W1482094025 creator A5033741912 @default.
- W1482094025 creator A5046784729 @default.
- W1482094025 creator A5066119178 @default.
- W1482094025 creator A5081039413 @default.
- W1482094025 creator A5084043720 @default.
- W1482094025 date "2006-04-15" @default.
- W1482094025 modified "2023-09-23" @default.
- W1482094025 title "Development and characterization of prostate specific antigen inhibitors" @default.
- W1482094025 hasPublicationYear "2006" @default.
- W1482094025 type Work @default.
- W1482094025 sameAs 1482094025 @default.
- W1482094025 citedByCount "0" @default.
- W1482094025 crossrefType "journal-article" @default.
- W1482094025 hasAuthorship W1482094025A5001771354 @default.
- W1482094025 hasAuthorship W1482094025A5010893381 @default.
- W1482094025 hasAuthorship W1482094025A5033741912 @default.
- W1482094025 hasAuthorship W1482094025A5046784729 @default.
- W1482094025 hasAuthorship W1482094025A5066119178 @default.
- W1482094025 hasAuthorship W1482094025A5081039413 @default.
- W1482094025 hasAuthorship W1482094025A5084043720 @default.
- W1482094025 hasConcept C121608353 @default.
- W1482094025 hasConcept C126322002 @default.
- W1482094025 hasConcept C147483822 @default.
- W1482094025 hasConcept C181199279 @default.
- W1482094025 hasConcept C182220744 @default.
- W1482094025 hasConcept C203014093 @default.
- W1482094025 hasConcept C2776235491 @default.
- W1482094025 hasConcept C2776414213 @default.
- W1482094025 hasConcept C2776714187 @default.
- W1482094025 hasConcept C2777807008 @default.
- W1482094025 hasConcept C2780192828 @default.
- W1482094025 hasConcept C2781114028 @default.
- W1482094025 hasConcept C2781406297 @default.
- W1482094025 hasConcept C502942594 @default.
- W1482094025 hasConcept C55493867 @default.
- W1482094025 hasConcept C71924100 @default.
- W1482094025 hasConcept C86803240 @default.
- W1482094025 hasConceptScore W1482094025C121608353 @default.
- W1482094025 hasConceptScore W1482094025C126322002 @default.
- W1482094025 hasConceptScore W1482094025C147483822 @default.
- W1482094025 hasConceptScore W1482094025C181199279 @default.
- W1482094025 hasConceptScore W1482094025C182220744 @default.
- W1482094025 hasConceptScore W1482094025C203014093 @default.
- W1482094025 hasConceptScore W1482094025C2776235491 @default.
- W1482094025 hasConceptScore W1482094025C2776414213 @default.
- W1482094025 hasConceptScore W1482094025C2776714187 @default.
- W1482094025 hasConceptScore W1482094025C2777807008 @default.
- W1482094025 hasConceptScore W1482094025C2780192828 @default.
- W1482094025 hasConceptScore W1482094025C2781114028 @default.
- W1482094025 hasConceptScore W1482094025C2781406297 @default.
- W1482094025 hasConceptScore W1482094025C502942594 @default.
- W1482094025 hasConceptScore W1482094025C55493867 @default.
- W1482094025 hasConceptScore W1482094025C71924100 @default.
- W1482094025 hasConceptScore W1482094025C86803240 @default.
- W1482094025 hasLocation W14820940251 @default.
- W1482094025 hasOpenAccess W1482094025 @default.
- W1482094025 hasPrimaryLocation W14820940251 @default.
- W1482094025 hasRelatedWork W111656656 @default.
- W1482094025 hasRelatedWork W1672322805 @default.
- W1482094025 hasRelatedWork W1982014262 @default.
- W1482094025 hasRelatedWork W2005286707 @default.
- W1482094025 hasRelatedWork W2008260093 @default.
- W1482094025 hasRelatedWork W2031648493 @default.
- W1482094025 hasRelatedWork W2035817663 @default.
- W1482094025 hasRelatedWork W2036048561 @default.
- W1482094025 hasRelatedWork W2070283207 @default.
- W1482094025 hasRelatedWork W2106982669 @default.
- W1482094025 hasRelatedWork W2140698185 @default.
- W1482094025 hasRelatedWork W2167891683 @default.
- W1482094025 hasRelatedWork W224921925 @default.
- W1482094025 hasRelatedWork W2404558512 @default.
- W1482094025 hasRelatedWork W2982210347 @default.
- W1482094025 hasRelatedWork W3112249937 @default.
- W1482094025 hasRelatedWork W3198676698 @default.
- W1482094025 hasRelatedWork W3200710469 @default.
- W1482094025 hasRelatedWork W97619605 @default.
- W1482094025 hasRelatedWork W2143410529 @default.
- W1482094025 hasVolume "66" @default.
- W1482094025 isParatext "false" @default.
- W1482094025 isRetracted "false" @default.
- W1482094025 magId "1482094025" @default.
- W1482094025 workType "article" @default.