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- W148211704 abstract "The last 10 years have seen the development of a large body of knowledge dealing with problems of the assembly of biological macromolecules into specific ordered structures. The ideas which have emerged from these studies may be regarded as an extension of the well established principle that the sequence of amino acid residues in a polypeptide chain is the main determinant of the complex folding of the chain into the native protein conformation. The concept of “self-folding” of the polypeptide chain was a natural starting point for dealing with the question of how macromolecules assemble themselves into large ordered structures for it introduced the idea that seemingly minor alterations in the microstructure of molecules can induce profound changes in their macrostructure." @default.
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- W148211704 date "1972-01-01" @default.
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- W148211704 title "Subunits to Superstructures: Assembly of Glutamate Dehydrogenase" @default.
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