FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1482140147> ?p ?o ?g. }

• W1482140147 endingPage "8282" @default.
• W1482140147 startingPage "8270" @default.
• W1482140147 abstract "Despite increased interest in inner ear hair cell regeneration, it is still unclear what exact mechanisms underlie hair cell regeneration in mammals because of our limited understanding of hair cell development and the lack of specific hair cell markers. In this report, we studied hair cell development using immunohistochemistry on sections prepared from embryonic day (E) 13 to postnatal day 7 rat inner ear tissues. Of many epithelial, neuronal, and glial markers, we found that calcium-binding protein antibodies recognizing calretinin, calmodulin, or parvalbumin labeled immature hair cells in rat vestibular end organs. In particular, calretinin antiserum labeled the initial differentiating hair cells at E15, a stage immediately after the terminal mitosis of hair cell progenitors. The selective immunoreactivity of postmitotic presumptive hair cells, but not supporting cells or peripheral epithelial cells, was confirmed in utricular epithelial sheet cultures. Double labeling with calretinin and bromodeoxyuridine antibodies in long-term cultures showed that only a few mitotic utricular supporting cells became calretinin positive. Thus, although proliferation-mediated regeneration of new hair cells might directly contribute to hair cell regeneration in rat utricles after injury, it is very limited. In addition, double labeling with calretinin and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) revealed that differentiated hair cells underwent apoptosis during normal development at late embryonic and early postnatal stages in vivo and in vitro. Therefore, these experiments lay the groundwork for the time course of differentiation, regeneration, and apoptosis of mammalian vestibular hair cells. This work also suggests that calcium-binding proteins are useful markers for studies on inner ear hair cell differentiation and regeneration." @default.
• W1482140147 created "2016-06-24" @default.
• W1482140147 creator A5081148554 @default.
• W1482140147 creator A5086877240 @default.
• W1482140147 date "1997-11-01" @default.
• W1482140147 modified "2023-10-13" @default.
• W1482140147 title "Analysis of Rat Vestibular Hair Cell Development and Regeneration Using Calretinin as an Early Marker" @default.
• W1482140147 cites W1489405221 @default.
• W1482140147 cites W1496964709 @default.
• W1482140147 cites W1521404049 @default.
• W1482140147 cites W1554177779 @default.
• W1482140147 cites W1558854951 @default.
• W1482140147 cites W1609471181 @default.
• W1482140147 cites W1664741673 @default.
• W1482140147 cites W1805838769 @default.
• W1482140147 cites W1808995917 @default.
• W1482140147 cites W1829932518 @default.
• W1482140147 cites W1884408152 @default.
• W1482140147 cites W1929144684 @default.
• W1482140147 cites W1968151061 @default.
• W1482140147 cites W1978750160 @default.
• W1482140147 cites W1979626228 @default.
• W1482140147 cites W1985074818 @default.
• W1482140147 cites W1985835614 @default.
• W1482140147 cites W1987145582 @default.
• W1482140147 cites W1990040978 @default.
• W1482140147 cites W1992673078 @default.
• W1482140147 cites W1992857468 @default.
• W1482140147 cites W1995048201 @default.
• W1482140147 cites W1995677728 @default.
• W1482140147 cites W1996777308 @default.
• W1482140147 cites W1997600733 @default.
• W1482140147 cites W1999559340 @default.
• W1482140147 cites W2000646975 @default.
• W1482140147 cites W2001372502 @default.
• W1482140147 cites W2001900968 @default.
• W1482140147 cites W2004107544 @default.
• W1482140147 cites W2010999141 @default.
• W1482140147 cites W2022706561 @default.
• W1482140147 cites W2023770379 @default.
• W1482140147 cites W2026120980 @default.
• W1482140147 cites W2027260046 @default.
• W1482140147 cites W2028916500 @default.
• W1482140147 cites W2042111556 @default.
• W1482140147 cites W2046972763 @default.
• W1482140147 cites W2047855572 @default.
• W1482140147 cites W2052594411 @default.
• W1482140147 cites W2057257609 @default.
• W1482140147 cites W2067986718 @default.
• W1482140147 cites W2069515096 @default.
• W1482140147 cites W2078660872 @default.
• W1482140147 cites W2086709816 @default.
• W1482140147 cites W2092910281 @default.
• W1482140147 cites W2093303203 @default.
• W1482140147 cites W2095931015 @default.
• W1482140147 cites W2113274822 @default.
• W1482140147 cites W2135601074 @default.
• W1482140147 cites W2137826349 @default.
• W1482140147 cites W2138580783 @default.
• W1482140147 cites W2139811837 @default.
• W1482140147 cites W2146714425 @default.
• W1482140147 cites W2154409385 @default.
• W1482140147 cites W2154745705 @default.
• W1482140147 cites W2163857939 @default.
• W1482140147 cites W2186244224 @default.
• W1482140147 cites W2407589319 @default.
• W1482140147 cites W2474609797 @default.
• W1482140147 cites W3208720944 @default.
• W1482140147 cites W3209258691 @default.
• W1482140147 cites W4252245240 @default.
• W1482140147 cites W4300988264 @default.
• W1482140147 cites W4302153216 @default.
• W1482140147 cites W4323284461 @default.
• W1482140147 doi "https://doi.org/10.1523/jneurosci.17-21-08270.1997" @default.
• W1482140147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573764" @default.
• W1482140147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9334402" @default.
• W1482140147 hasPublicationYear "1997" @default.
• W1482140147 type Work @default.
• W1482140147 sameAs 1482140147 @default.
• W1482140147 citedByCount "117" @default.
• W1482140147 countsByYear W14821401472012 @default.
• W1482140147 countsByYear W14821401472013 @default.
• W1482140147 countsByYear W14821401472014 @default.
• W1482140147 countsByYear W14821401472015 @default.
• W1482140147 countsByYear W14821401472016 @default.
• W1482140147 countsByYear W14821401472017 @default.
• W1482140147 countsByYear W14821401472018 @default.
• W1482140147 countsByYear W14821401472019 @default.
• W1482140147 countsByYear W14821401472021 @default.
• W1482140147 countsByYear W14821401472022 @default.
• W1482140147 countsByYear W14821401472023 @default.
• W1482140147 crossrefType "journal-article" @default.
• W1482140147 hasAuthorship W1482140147A5081148554 @default.
• W1482140147 hasAuthorship W1482140147A5086877240 @default.
• W1482140147 hasBestOaLocation W14821401471 @default.
• W1482140147 hasConcept C105702510 @default.
• W1482140147 hasConcept C154113507 @default.
• W1482140147 hasConcept C171056886 @default.

• next