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- W1482201030 abstract "Given genetic marker data on unrelated individuals, maximum-likelihood allele-frequency estimates and their standard errors are easily calculated from sample proportions. When marker phenotypes are observed on relatives, this method cannot be used without either discarding a subset of the data or incorrectly assuming that all individuals are unrelated. Here, I describe a method for allele frequency estimation for data on relatives that is based on standard methods of pedigree analysis. This method makes use of all available marker information while correctly taking into account the dependence between relatives. I illustrate use of the method with family data for a VNTR polymorphism near the apolipoprotein B locus." @default.
- W1482201030 created "2016-06-24" @default.
- W1482201030 creator A5059450341 @default.
- W1482201030 date "1991-01-01" @default.
- W1482201030 modified "2023-10-17" @default.
- W1482201030 title "Allele frequency estimation from data on relatives." @default.
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- W1482201030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1682747" @default.
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