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• W1482202017 abstract "Abstract Background: There have been genetic studies assessing the association between tumor necrosis factor (TNF)‐α‐308 and Kawasaki disease (KD) but the results have been conflicting due to lack of power. Therefore, a systematic review and meta‐analysis was conducted to increase the power for identifying the association between the TNF‐α‐308 polymorphism and KD. Method: Studies were identified from MEDLINE and EMBASE databases and were included if the subjects were children and the frequencies between TNF‐α‐308 and KD were reported. Data were pooled using a random effect model if heterogeneity between studies was present. Results: Thirteen studies were identified however only six studies were included. The pooled prevalence of minor A allele was 5.2% (95% confidence interval [CI]: 0.1%–9.5%). Gene effect was assessed using per‐allele and per‐genotype approaches. The pooled odds ratio of G versus A with the random effect model was 1.13 (95%CI: 0.34–3.27). The genotype effects for GG versus GA+AA was estimated and the pooled odds ratio was 1.08 (95%CI: 0.42–2.92). Conclusion: This review suggests a trend of association between the TNF‐α‐308 G‐allele and KD. However, the gene effects are heterogeneous and assessing sources of heterogeneity are limited. An updated meta‐analysis is needed if more studies are published." @default.
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• W1482202017 creator A5053331577 @default.
• W1482202017 creator A5056464791 @default.
• W1482202017 date "2010-08-01" @default.
• W1482202017 modified "2023-10-16" @default.
• W1482202017 title "A systematic review and meta-analysis of tumor necrosis factor α-308 polymorphism and Kawasaki disease" @default.
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• W1482202017 doi "https://doi.org/10.1111/j.1442-200x.2010.03105.x" @default.
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