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• W1482253398 abstract "This chapter discusses the recent advances made on the properties and role of Ca2+-activated chloride currents in smooth muscles. Calcium-activated chloride currents (ICl(Ca)) are recorded in isolated cells of many smooth muscle types and there is significant evidence that this membrane conductance has a functional role in producing contraction in intact smooth muscle tissues. The mechanism by which Ca2+ activates the channel is unknown and the manner by which this activation occurs appears to alter the kinetics and also the pharmacological sensitivity of the channel. In comparison to some non-muscle cells, the activation of the channel by Ca2+ does not seem to be through CaMKII-dependent phosphorylation. In fact, CaMII-dependent phosphorylation suppresses channel activation to some extent in arterial and tracheal preparations, but appears to have less of a role in channel regulation in portal vein cells. The determination of the processes that modulate the activity of ICl(Ca) would be facilitated by knowing the protein structure of the underlying channel." @default.
• W1482253398 created "2016-06-24" @default.
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• W1482253398 date "2002-01-01" @default.
• W1482253398 modified "2023-09-26" @default.
• W1482253398 title "Recent advances on the properties and role of Ca2+-activated chloride currents in smooth muscle" @default.
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• W1482253398 doi "https://doi.org/10.1016/s1063-5823(02)53030-1" @default.
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