Matches in SemOpenAlex for { <https://semopenalex.org/work/W1482534971> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1482534971 abstract "Cardiac ryanodine receptor 2 (RyR2) is critical to the electrical homeostasis of cardiomyocytes. Its gene variant rs3766871 entails channel destabilization and enhanced intracellular Ca(2+) oscillation, thus promoting cardiac arrhythmias. We investigated whether the RyR2 rs3766871 variant is associated with aborted sudden cardiac death or ICD therapy for ventricular tachycardia (VT)/fibrillation (VF) in heart failure (HF) patients implanted with a cardioverter defibrillator (ICD).A total of 183 HF patients with primary or secondary prevention ICD were divided in 2 groups. A VT/VF group was composed of secondary prevention patients and primary prevention patients with appropriate ICD intervention for VT/VF. An ICD control group was composed of primary prevention patients free from any appropriate ICD intervention after 43 ± 25 months follow-up. Study subjects were genotyped with respect to the rs3766871 RyR2 gene variant. Hazard ratios (HRs) were derived from Cox proportional-hazards regression analysis. In all, 56 patients constituted the VT/VF group and 127 patients the ICD control group. Male sex (HR: 3.02; 95% CI: 0.99-9.18; P = 0.05), atrial fibrillation (AF; HR: 2.33; 95% CI: 0.89-6.10; P = 0.08), and underuse of β-blockers (HR: 2.08; 95% CI: 0.84-5.15; P = 0.11) were associated with the VT/VF phenotype. Prevalence of the rs3766871 minor allele was 2.8% in ICD control patients and 8.0% in the VT/VF group (P = 0.02). After adjustment for age, sex, AF, and use of β-blockers, the rs3766871 minor allele was associated with increased risk of VT/VF (HR: 3.49; 95% CI: 1.14-10.62; P = 0.02).Our study identifies a significant role of RyR2 rs3766871 minor allele for increased susceptibility to VT/VF in a population of ICD patients with HF." @default.
- W1482534971 created "2016-06-24" @default.
- W1482534971 creator A5001834437 @default.
- W1482534971 creator A5010927128 @default.
- W1482534971 creator A5013043454 @default.
- W1482534971 creator A5014008036 @default.
- W1482534971 creator A5018284638 @default.
- W1482534971 creator A5019161572 @default.
- W1482534971 creator A5028634699 @default.
- W1482534971 creator A5054282642 @default.
- W1482534971 creator A5072021112 @default.
- W1482534971 creator A5074837327 @default.
- W1482534971 creator A5078109300 @default.
- W1482534971 creator A5081859637 @default.
- W1482534971 date "2015-05-01" @default.
- W1482534971 modified "2023-09-23" @default.
- W1482534971 title "RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure" @default.
- W1482534971 cites W1972324925 @default.
- W1482534971 cites W1974942493 @default.
- W1482534971 cites W1981674309 @default.
- W1482534971 cites W1986328966 @default.
- W1482534971 cites W2009039495 @default.
- W1482534971 cites W2018260333 @default.
- W1482534971 cites W2033039093 @default.
- W1482534971 cites W2053060412 @default.
- W1482534971 cites W2055023809 @default.
- W1482534971 cites W2083132173 @default.
- W1482534971 cites W2088050791 @default.
- W1482534971 cites W2106754238 @default.
- W1482534971 cites W2109230866 @default.
- W1482534971 cites W2133840225 @default.
- W1482534971 cites W2162353952 @default.
- W1482534971 doi "https://doi.org/10.1111/jce.12658" @default.
- W1482534971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25773045" @default.
- W1482534971 hasPublicationYear "2015" @default.
- W1482534971 type Work @default.
- W1482534971 sameAs 1482534971 @default.
- W1482534971 citedByCount "3" @default.
- W1482534971 countsByYear W14825349712018 @default.
- W1482534971 countsByYear W14825349712020 @default.
- W1482534971 countsByYear W14825349712021 @default.
- W1482534971 crossrefType "journal-article" @default.
- W1482534971 hasAuthorship W1482534971A5001834437 @default.
- W1482534971 hasAuthorship W1482534971A5010927128 @default.
- W1482534971 hasAuthorship W1482534971A5013043454 @default.
- W1482534971 hasAuthorship W1482534971A5014008036 @default.
- W1482534971 hasAuthorship W1482534971A5018284638 @default.
- W1482534971 hasAuthorship W1482534971A5019161572 @default.
- W1482534971 hasAuthorship W1482534971A5028634699 @default.
- W1482534971 hasAuthorship W1482534971A5054282642 @default.
- W1482534971 hasAuthorship W1482534971A5072021112 @default.
- W1482534971 hasAuthorship W1482534971A5074837327 @default.
- W1482534971 hasAuthorship W1482534971A5078109300 @default.
- W1482534971 hasAuthorship W1482534971A5081859637 @default.
- W1482534971 hasConcept C113217602 @default.
- W1482534971 hasConcept C126322002 @default.
- W1482534971 hasConcept C164705383 @default.
- W1482534971 hasConcept C170493617 @default.
- W1482534971 hasConcept C190712762 @default.
- W1482534971 hasConcept C207103383 @default.
- W1482534971 hasConcept C2775935837 @default.
- W1482534971 hasConcept C2776331378 @default.
- W1482534971 hasConcept C2777093960 @default.
- W1482534971 hasConcept C2778198053 @default.
- W1482534971 hasConcept C2779161974 @default.
- W1482534971 hasConcept C2781005686 @default.
- W1482534971 hasConcept C44249647 @default.
- W1482534971 hasConcept C71924100 @default.
- W1482534971 hasConceptScore W1482534971C113217602 @default.
- W1482534971 hasConceptScore W1482534971C126322002 @default.
- W1482534971 hasConceptScore W1482534971C164705383 @default.
- W1482534971 hasConceptScore W1482534971C170493617 @default.
- W1482534971 hasConceptScore W1482534971C190712762 @default.
- W1482534971 hasConceptScore W1482534971C207103383 @default.
- W1482534971 hasConceptScore W1482534971C2775935837 @default.
- W1482534971 hasConceptScore W1482534971C2776331378 @default.
- W1482534971 hasConceptScore W1482534971C2777093960 @default.
- W1482534971 hasConceptScore W1482534971C2778198053 @default.
- W1482534971 hasConceptScore W1482534971C2779161974 @default.
- W1482534971 hasConceptScore W1482534971C2781005686 @default.
- W1482534971 hasConceptScore W1482534971C44249647 @default.
- W1482534971 hasConceptScore W1482534971C71924100 @default.
- W1482534971 hasLocation W14825349711 @default.
- W1482534971 hasLocation W14825349712 @default.
- W1482534971 hasOpenAccess W1482534971 @default.
- W1482534971 hasPrimaryLocation W14825349711 @default.
- W1482534971 hasRelatedWork W1491147932 @default.
- W1482534971 hasRelatedWork W2083132173 @default.
- W1482534971 hasRelatedWork W2085690302 @default.
- W1482534971 hasRelatedWork W2127485861 @default.
- W1482534971 hasRelatedWork W2148566864 @default.
- W1482534971 hasRelatedWork W236717508 @default.
- W1482534971 hasRelatedWork W2791219437 @default.
- W1482534971 hasRelatedWork W2896445697 @default.
- W1482534971 hasRelatedWork W4280530690 @default.
- W1482534971 hasRelatedWork W4283276396 @default.
- W1482534971 isParatext "false" @default.
- W1482534971 isRetracted "false" @default.
- W1482534971 magId "1482534971" @default.
- W1482534971 workType "article" @default.