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- W1482536944 abstract "The relation of true isovolumic contraction time with two external indexes of ventricular performance was studied in intact anesthetized dogs utilizing end-catheter micromanometers in the left ventricle and central aorta. The external indexes studied were (1) the pre-ejection period, the interval from the Q wave of the electrocardiogram to the aortic component of the second sound minus left ventricular ejection time; and (2) external isovolumic contraction time, the interval from the first heart sound to the aortic component of the second sound minus left ventricular ejection time. The isovolumic contraction time was shortened from the resting value by administration of isoproterenol and lengthened by vagal stimulation and administration of methoxamine. Excellent linear correlations were found between absolute values of true isovolumic contraction time and the two indexes during all interventions. When changes from control true isovolumic contraction time were plotted against similar changes in the pre-ejection period and external isovolumic contraction time, better linear correlations were found. In addition, the inverse relation between true isovolumic contraction time and the first derivative of left ventricular pressure (dp/dt) in the intact animal was reflected by the pre-ejection period and external isovolumic contraction time. The two external indexes were therefore shown to reflect reliably changes in true isovolumic contraction time. When changes in diastolic blood pressure are considered, and with only small alterations occurring in left ventricular end-diastolic pressure, they give useful information about changes in ventricular performance including an estimation of changes in left ventricular dp/dt. They relate directly to contractility only when diastolic pressure remains constant." @default.
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- W1482536944 date "1970-04-01" @default.
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- W1482536944 title "True isovolumic contraction time" @default.
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- W1482536944 doi "https://doi.org/10.1016/0002-9149(70)90010-x" @default.
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