Matches in SemOpenAlex for { <https://semopenalex.org/work/W1482778630> ?p ?o ?g. }
- W1482778630 endingPage "378" @default.
- W1482778630 startingPage "359" @default.
- W1482778630 abstract "Derangement of the nuclear factor κB (NF-κB) pathway initiates and/or sustains many types of human cancer. B-cell malignancies are particularly affected by oncogenic mutations, translocations, and copy number alterations affecting key components the NF-κB pathway, most likely owing to the pervasive role of this pathway in normal B cells. These genetic aberrations cause tumors to be 'addicted' to NF-κB, which can be exploited therapeutically. Since each subtype of lymphoid cancer utilizes different mechanisms to activate NF-κB, several different therapeutic strategies are needed to address this pathogenetic heterogeneity. Fortunately, a number of drugs that block signaling cascades leading to NF-κB are in early phase clinical trials, several of which are already showing activity in lymphoid malignancies." @default.
- W1482778630 created "2016-06-24" @default.
- W1482778630 creator A5025942951 @default.
- W1482778630 creator A5057678044 @default.
- W1482778630 creator A5080642100 @default.
- W1482778630 date "2012-03-01" @default.
- W1482778630 modified "2023-10-01" @default.
- W1482778630 title "Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies" @default.
- W1482778630 cites W1494529291 @default.
- W1482778630 cites W1501881225 @default.
- W1482778630 cites W1520695706 @default.
- W1482778630 cites W1554981631 @default.
- W1482778630 cites W1563487810 @default.
- W1482778630 cites W1621883807 @default.
- W1482778630 cites W1759028523 @default.
- W1482778630 cites W1817295032 @default.
- W1482778630 cites W1915085848 @default.
- W1482778630 cites W1937502920 @default.
- W1482778630 cites W1949280308 @default.
- W1482778630 cites W1960809236 @default.
- W1482778630 cites W1965971815 @default.
- W1482778630 cites W1967139887 @default.
- W1482778630 cites W1968178844 @default.
- W1482778630 cites W1969501356 @default.
- W1482778630 cites W1971659434 @default.
- W1482778630 cites W1972866849 @default.
- W1482778630 cites W1973562447 @default.
- W1482778630 cites W1975293480 @default.
- W1482778630 cites W1976402300 @default.
- W1482778630 cites W1976564639 @default.
- W1482778630 cites W1976590012 @default.
- W1482778630 cites W1977348505 @default.
- W1482778630 cites W1977592286 @default.
- W1482778630 cites W1977642281 @default.
- W1482778630 cites W1978019581 @default.
- W1482778630 cites W1979059478 @default.
- W1482778630 cites W1979816280 @default.
- W1482778630 cites W1981295756 @default.
- W1482778630 cites W1981403111 @default.
- W1482778630 cites W1982008474 @default.
- W1482778630 cites W1982022868 @default.
- W1482778630 cites W1982905137 @default.
- W1482778630 cites W1984358344 @default.
- W1482778630 cites W1984785868 @default.
- W1482778630 cites W1985007837 @default.
- W1482778630 cites W1987531976 @default.
- W1482778630 cites W1988703453 @default.
- W1482778630 cites W1988858346 @default.
- W1482778630 cites W1990033823 @default.
- W1482778630 cites W1990089954 @default.
- W1482778630 cites W1992320631 @default.
- W1482778630 cites W1992841021 @default.
- W1482778630 cites W1993211211 @default.
- W1482778630 cites W1993355130 @default.
- W1482778630 cites W1993687272 @default.
- W1482778630 cites W1993731501 @default.
- W1482778630 cites W1993906107 @default.
- W1482778630 cites W1993936200 @default.
- W1482778630 cites W1995747121 @default.
- W1482778630 cites W1996699413 @default.
- W1482778630 cites W1998003228 @default.
- W1482778630 cites W1998585620 @default.
- W1482778630 cites W1998660354 @default.
- W1482778630 cites W1999104287 @default.
- W1482778630 cites W2003262666 @default.
- W1482778630 cites W2003603336 @default.
- W1482778630 cites W2004980094 @default.
- W1482778630 cites W2006338784 @default.
- W1482778630 cites W2006342636 @default.
- W1482778630 cites W2007886976 @default.
- W1482778630 cites W2010479391 @default.
- W1482778630 cites W2011345683 @default.
- W1482778630 cites W2011443550 @default.
- W1482778630 cites W2013417742 @default.
- W1482778630 cites W2016116811 @default.
- W1482778630 cites W2016162029 @default.
- W1482778630 cites W2016246269 @default.
- W1482778630 cites W2017883909 @default.
- W1482778630 cites W2018705412 @default.
- W1482778630 cites W2019655196 @default.
- W1482778630 cites W2023032337 @default.
- W1482778630 cites W2025786205 @default.
- W1482778630 cites W2026214119 @default.
- W1482778630 cites W2027569621 @default.
- W1482778630 cites W2027971058 @default.
- W1482778630 cites W2028330103 @default.
- W1482778630 cites W2028871868 @default.
- W1482778630 cites W2029295983 @default.
- W1482778630 cites W2029454644 @default.
- W1482778630 cites W2030262603 @default.
- W1482778630 cites W2031162215 @default.
- W1482778630 cites W2031855605 @default.
- W1482778630 cites W2032095580 @default.
- W1482778630 cites W2035135710 @default.
- W1482778630 cites W2035245019 @default.
- W1482778630 cites W2035679764 @default.
- W1482778630 cites W2037796411 @default.
- W1482778630 cites W2038053631 @default.