FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1482790870> ?p ?o ?g. }

• W1482790870 endingPage "4412" @default.
• W1482790870 startingPage "4397" @default.
• W1482790870 abstract "Abstract Tumor-associated immunosuppression aids cancer cells to escape immune-mediated attack and subsequent elimination. Recently, however, many oncolytic viruses, including reovirus, have been reported to overturn such immunosuppression and promote the development of a clinically desired antitumor immunity, which is known to promote favorable patient outcomes. Contrary to this existing paradigm, in this article we demonstrate that reovirus augments tumor-associated immunosuppression immediately following its therapeutic administration. Our data show that reovirus induces preferential differentiation of highly suppressive CD11b+, Gr-1+, Ly6Chigh myeloid cells from bone marrow hematopoietic progenitor cells. Furthermore, reovirus administration in tumor-bearing hosts drives time-dependent recruitment of CD11b+, Gr-1+, Ly6Chigh myeloid cells in the tumor milieu, which is further supported by virus-induced increased expression of numerous immune factors involved in myeloid-derived suppressor cell survival and trafficking. Most importantly, CD11b+, Gr-1+, Ly6Chigh myeloid cells specifically potentiate the suppression of T cell proliferation and are associated with the absence of IFN-γ response in the tumor microenvironment early during oncotherapy. Considering that the qualitative traits of a specific antitumor immunity are largely dictated by the immunological events that precede its development, our findings are of critical importance and must be considered while devising complementary interventions aimed at promoting the optimum efficacy of oncolytic virus–based anticancer immunotherapies." @default.
• W1482790870 created "2016-06-24" @default.
• W1482790870 creator A5001180776 @default.
• W1482790870 creator A5004261817 @default.
• W1482790870 creator A5018113275 @default.
• W1482790870 creator A5025029978 @default.
• W1482790870 creator A5028232488 @default.
• W1482790870 creator A5046392619 @default.
• W1482790870 creator A5049303637 @default.
• W1482790870 creator A5057479940 @default.
• W1482790870 creator A5068650401 @default.
• W1482790870 creator A5088287164 @default.
• W1482790870 creator A5090850043 @default.
• W1482790870 date "2015-05-01" @default.
• W1482790870 modified "2023-10-11" @default.
• W1482790870 title "Newly Recruited CD11b+, GR-1+, Ly6Chigh Myeloid Cells Augment Tumor-Associated Immunosuppression Immediately following the Therapeutic Administration of Oncolytic Reovirus" @default.
• W1482790870 cites W1536028944 @default.
• W1482790870 cites W1854596437 @default.
• W1482790870 cites W1933912253 @default.
• W1482790870 cites W1978183014 @default.
• W1482790870 cites W1984700615 @default.
• W1482790870 cites W1986462840 @default.
• W1482790870 cites W1999325713 @default.
• W1482790870 cites W2004150448 @default.
• W1482790870 cites W2009211019 @default.
• W1482790870 cites W2011627030 @default.
• W1482790870 cites W2012654541 @default.
• W1482790870 cites W2023310830 @default.
• W1482790870 cites W2024040080 @default.
• W1482790870 cites W2027873984 @default.
• W1482790870 cites W2036869628 @default.
• W1482790870 cites W2044835625 @default.
• W1482790870 cites W2045327923 @default.
• W1482790870 cites W2048134603 @default.
• W1482790870 cites W2048434210 @default.
• W1482790870 cites W2058036025 @default.
• W1482790870 cites W2059492353 @default.
• W1482790870 cites W2060672294 @default.
• W1482790870 cites W2061869265 @default.
• W1482790870 cites W2068302554 @default.
• W1482790870 cites W2077141971 @default.
• W1482790870 cites W2082767963 @default.
• W1482790870 cites W2090599158 @default.
• W1482790870 cites W2094366129 @default.
• W1482790870 cites W2100213157 @default.
• W1482790870 cites W2102194082 @default.
• W1482790870 cites W2102833781 @default.
• W1482790870 cites W2105459360 @default.
• W1482790870 cites W2107277218 @default.
• W1482790870 cites W2110271242 @default.
• W1482790870 cites W2111415894 @default.
• W1482790870 cites W2111687357 @default.
• W1482790870 cites W2111954625 @default.
• W1482790870 cites W2113845760 @default.
• W1482790870 cites W2119677763 @default.
• W1482790870 cites W2128553155 @default.
• W1482790870 cites W2128892990 @default.
• W1482790870 cites W2136911804 @default.
• W1482790870 cites W2137074525 @default.
• W1482790870 cites W2141383323 @default.
• W1482790870 cites W2144269899 @default.
• W1482790870 cites W2148676724 @default.
• W1482790870 cites W2155464294 @default.
• W1482790870 cites W2157269800 @default.
• W1482790870 cites W2163492712 @default.
• W1482790870 cites W2165064029 @default.
• W1482790870 cites W2171249989 @default.
• W1482790870 cites W2171283491 @default.
• W1482790870 cites W2209812019 @default.
• W1482790870 cites W32691376 @default.
• W1482790870 doi "https://doi.org/10.4049/jimmunol.1402132" @default.
• W1482790870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25825443" @default.
• W1482790870 hasPublicationYear "2015" @default.
• W1482790870 type Work @default.
• W1482790870 sameAs 1482790870 @default.
• W1482790870 citedByCount "30" @default.
• W1482790870 countsByYear W14827908702015 @default.
• W1482790870 countsByYear W14827908702016 @default.
• W1482790870 countsByYear W14827908702017 @default.
• W1482790870 countsByYear W14827908702018 @default.
• W1482790870 countsByYear W14827908702019 @default.
• W1482790870 countsByYear W14827908702020 @default.
• W1482790870 countsByYear W14827908702021 @default.
• W1482790870 countsByYear W14827908702022 @default.
• W1482790870 countsByYear W14827908702023 @default.
• W1482790870 crossrefType "journal-article" @default.
• W1482790870 hasAuthorship W1482790870A5001180776 @default.
• W1482790870 hasAuthorship W1482790870A5004261817 @default.
• W1482790870 hasAuthorship W1482790870A5018113275 @default.
• W1482790870 hasAuthorship W1482790870A5025029978 @default.
• W1482790870 hasAuthorship W1482790870A5028232488 @default.
• W1482790870 hasAuthorship W1482790870A5046392619 @default.
• W1482790870 hasAuthorship W1482790870A5049303637 @default.
• W1482790870 hasAuthorship W1482790870A5057479940 @default.
• W1482790870 hasAuthorship W1482790870A5068650401 @default.
• W1482790870 hasAuthorship W1482790870A5088287164 @default.
• W1482790870 hasAuthorship W1482790870A5090850043 @default.
• W1482790870 hasBestOaLocation W14827908701 @default.

• next