FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1482829834> ?p ?o ?g. }

• W1482829834 endingPage "950" @default.
• W1482829834 startingPage "941" @default.
• W1482829834 abstract "The release of arachidonic acid from cellular phospholipids and its subsequent conversion to eicosanoids is the common early response of skin keratinocytes to a wide variety of exogenous or endogenous agonists including irritant skin mitogens such as the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA) or the inflammatory peptide bradykinin. In mouse keratinocytes labeled with [14C]arachidonic acid, both PMA and bradykinin induced the release of the fatty acid in a dose-dependent and time-dependent manner. Three lines of evidence indicate phospholipase A2 activity to be involved in arachidonic acid release: (a) its inhibition by mepacrine, (b) the concomitant generation of lysophosphatidylcholine from [3H]choline-labeled cells and (c) an increase in arachidonic acid release from 14C-labeled phosphatidylcholine in particulate fractions from PMA-treated and bradykinin-treated keratinocytes. Inhibition or down regulation of protein kinase C (PKC) led to a suppression of PMA-induced but not bradykinin-induced arachidonic acid release, indicating a critical involvement of this kinase in phorbol-ester-induced activation of epidermal phospholipase A2 activity. Bradykinin-induced activation of phospholipase A2 was however, shown to be mediated by specific B2 receptors coupled to GTP-binding proteins (G protein). In support of this mechanism it was demonstrated that the bradykinin-induced phospholipase A2 activity was increased in the presence of non-hydrolysable GTP but decreased upon addition of non-hydrolysable GDP analogues. Moreover, cholera toxin stimulated both basal and bradykinin-induced phospholipase A2 activity in a cAMP-independent manner, whereas pertussis toxin was found to be inactive in this respect. The data suggest that epidermal phospholipase A2 activity can be stimulated by bradykinin via a B2 receptor-G-protein-dependent pathway, which is independent of PKC and a PKC-dependent pathway which is activated by phorbol esters such as PMA." @default.
• W1482829834 created "2016-06-24" @default.
• W1482829834 creator A5007487924 @default.
• W1482829834 creator A5033097711 @default.
• W1482829834 creator A5080601032 @default.
• W1482829834 date "1991-12-01" @default.
• W1482829834 modified "2023-10-02" @default.
• W1482829834 title "Activation of a keratinocyte phospholipase A2 by bradykinin and 4beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediatd mechanism" @default.
• W1482829834 cites W1502032494 @default.
• W1482829834 cites W1508152421 @default.
• W1482829834 cites W1517930566 @default.
• W1482829834 cites W1522405441 @default.
• W1482829834 cites W1544929992 @default.
• W1482829834 cites W1560653093 @default.
• W1482829834 cites W1581449994 @default.
• W1482829834 cites W1586296071 @default.
• W1482829834 cites W1590150548 @default.
• W1482829834 cites W1591896969 @default.
• W1482829834 cites W1595133660 @default.
• W1482829834 cites W1596708629 @default.
• W1482829834 cites W1821651100 @default.
• W1482829834 cites W1927532555 @default.
• W1482829834 cites W1927894522 @default.
• W1482829834 cites W1966427545 @default.
• W1482829834 cites W1967156295 @default.
• W1482829834 cites W1983649348 @default.
• W1482829834 cites W1984787065 @default.
• W1482829834 cites W1985887257 @default.
• W1482829834 cites W1989540637 @default.
• W1482829834 cites W1994556559 @default.
• W1482829834 cites W1994613176 @default.
• W1482829834 cites W2009217711 @default.
• W1482829834 cites W2027892263 @default.
• W1482829834 cites W2031677004 @default.
• W1482829834 cites W2031683755 @default.
• W1482829834 cites W2035746389 @default.
• W1482829834 cites W2040595849 @default.
• W1482829834 cites W2049688520 @default.
• W1482829834 cites W2054917742 @default.
• W1482829834 cites W2058164106 @default.
• W1482829834 cites W2059421144 @default.
• W1482829834 cites W2061319253 @default.
• W1482829834 cites W2063535351 @default.
• W1482829834 cites W2067623381 @default.
• W1482829834 cites W2073453629 @default.
• W1482829834 cites W2077301263 @default.
• W1482829834 cites W2081165771 @default.
• W1482829834 cites W2082637429 @default.
• W1482829834 cites W2085019095 @default.
• W1482829834 cites W2100837269 @default.
• W1482829834 cites W2108535629 @default.
• W1482829834 cites W2114830145 @default.
• W1482829834 cites W2171322145 @default.
• W1482829834 cites W2228238583 @default.
• W1482829834 cites W2261589407 @default.
• W1482829834 cites W2323350104 @default.
• W1482829834 cites W48759033 @default.
• W1482829834 doi "https://doi.org/10.1111/j.1432-1033.1991.tb16454.x" @default.
• W1482829834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1662619" @default.
• W1482829834 hasPublicationYear "1991" @default.
• W1482829834 type Work @default.
• W1482829834 sameAs 1482829834 @default.
• W1482829834 citedByCount "34" @default.
• W1482829834 countsByYear W14828298342021 @default.
• W1482829834 crossrefType "journal-article" @default.
• W1482829834 hasAuthorship W1482829834A5007487924 @default.
• W1482829834 hasAuthorship W1482829834A5033097711 @default.
• W1482829834 hasAuthorship W1482829834A5080601032 @default.
• W1482829834 hasBestOaLocation W14828298341 @default.
• W1482829834 hasConcept C118716 @default.
• W1482829834 hasConcept C12927208 @default.
• W1482829834 hasConcept C170493617 @default.
• W1482829834 hasConcept C181199279 @default.
• W1482829834 hasConcept C185592680 @default.
• W1482829834 hasConcept C195794163 @default.
• W1482829834 hasConcept C2776330855 @default.
• W1482829834 hasConcept C2776551241 @default.
• W1482829834 hasConcept C2778078955 @default.
• W1482829834 hasConcept C2778596009 @default.
• W1482829834 hasConcept C2778597717 @default.
• W1482829834 hasConcept C2778918659 @default.
• W1482829834 hasConcept C2779591629 @default.
• W1482829834 hasConcept C2780043322 @default.
• W1482829834 hasConcept C41625074 @default.
• W1482829834 hasConcept C49773422 @default.
• W1482829834 hasConcept C55493867 @default.
• W1482829834 hasConcept C62478195 @default.
• W1482829834 hasConcept C80631254 @default.
• W1482829834 hasConceptScore W1482829834C118716 @default.
• W1482829834 hasConceptScore W1482829834C12927208 @default.
• W1482829834 hasConceptScore W1482829834C170493617 @default.
• W1482829834 hasConceptScore W1482829834C181199279 @default.
• W1482829834 hasConceptScore W1482829834C185592680 @default.
• W1482829834 hasConceptScore W1482829834C195794163 @default.
• W1482829834 hasConceptScore W1482829834C2776330855 @default.
• W1482829834 hasConceptScore W1482829834C2776551241 @default.
• W1482829834 hasConceptScore W1482829834C2778078955 @default.
• W1482829834 hasConceptScore W1482829834C2778596009 @default.

• next