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- W1483004490 abstract "We report on the synthesis of two series of 1,4-naphthohydroquinone derivatives conjugated with amino acids (Gly, Ala, Phe, and Glu) and with substituted purines linked by an aliphatic chain. The compounds were obtained through Diels–Alder cycloaddition between myrcene and 1,4-benzoquinone and evaluated in vitro for their cytotoxicity (GI50) against cultured human cancer cells of A-549 lung carcinoma, HT-29 colon adenocarcinoma, and MCF-7 breast carcinoma. The GI50 values found for some hydroquinone–amino acid and hydroquinone–purine hybrids against MCF-7 are in an activity range comparable to that of the reference drug doxorubicin." @default.
- W1483004490 created "2016-06-24" @default.
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- W1483004490 date "2013-10-14" @default.
- W1483004490 modified "2023-09-29" @default.
- W1483004490 title "Synthesis and Evaluation as Antitumor Agents of 1,4-Naphthohydroquinone Derivatives Conjugated with Amino Acids and Purines" @default.
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- W1483004490 doi "https://doi.org/10.1002/ardp.201300137" @default.
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