Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483014538> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1483014538 endingPage "434" @default.
- W1483014538 startingPage "430" @default.
- W1483014538 abstract "Summary 1. Antithrombotic agents are effective in the treatment of ischaemic stroke. Timosaponin B‐II (TB‐II) is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae; rhizome) that has protective effects against cerebral ischaemic damage. The present study examined the antiplatelet and antithrombotic actions of TB‐II. 2. In in vitro experiments, TB‐II (20, 40 and 80 mg/mL) potently and dose‐dependently inhibited ADP‐induced platelet aggregation. Furthermore, 1, 3 and 6 mg/kg TB‐II prolonged activated partial thromboplastin time by 9.29, 16.86 and 25.50%, respectively, but had no effect on the prothrombin time. Furthermore, 1, 3 and 6 mg/kg TB‐II significantly reduced the wet weight, dry weight and length of the thrombi (%inhibition (based on wet weight): 13.6, 19.8 and 24.7%, respectively). 3. In a rabbit arteriovenous shunt model, 1, 3 and 6 mg/kg, i.v., TB‐II had no effect on thrombus formation. Plasma euglobulin lysis time and fibrin degradation product were not affected by 1, 3 and 6 mg/kg TB‐II, but plasminogen levels were decreased significantly by 14.4, 18.3 and 29.0%, respectively. 4. The results of the present study demonstrate significant antiplatelet and anticoagulation effects of TB‐II and suggest that these actions could contribute to its neuroprotective effect against damage following cerebral ischaemia damage." @default.
- W1483014538 created "2016-06-24" @default.
- W1483014538 creator A5033136225 @default.
- W1483014538 creator A5033846884 @default.
- W1483014538 creator A5050563694 @default.
- W1483014538 creator A5054650769 @default.
- W1483014538 creator A5067271160 @default.
- W1483014538 creator A5088251604 @default.
- W1483014538 date "2011-06-27" @default.
- W1483014538 modified "2023-10-17" @default.
- W1483014538 title "Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides" @default.
- W1483014538 cites W1965752697 @default.
- W1483014538 cites W1985347943 @default.
- W1483014538 cites W1993361645 @default.
- W1483014538 cites W2006169072 @default.
- W1483014538 cites W2014732010 @default.
- W1483014538 cites W2021915944 @default.
- W1483014538 cites W2037891603 @default.
- W1483014538 cites W2070856810 @default.
- W1483014538 cites W2077196831 @default.
- W1483014538 cites W2077905843 @default.
- W1483014538 cites W2082405107 @default.
- W1483014538 cites W2098276516 @default.
- W1483014538 cites W2289374845 @default.
- W1483014538 cites W2333712144 @default.
- W1483014538 cites W2338122996 @default.
- W1483014538 cites W4256116447 @default.
- W1483014538 doi "https://doi.org/10.1111/j.1440-1681.2011.05530.x" @default.
- W1483014538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21517935" @default.
- W1483014538 hasPublicationYear "2011" @default.
- W1483014538 type Work @default.
- W1483014538 sameAs 1483014538 @default.
- W1483014538 citedByCount "41" @default.
- W1483014538 countsByYear W14830145382012 @default.
- W1483014538 countsByYear W14830145382013 @default.
- W1483014538 countsByYear W14830145382014 @default.
- W1483014538 countsByYear W14830145382015 @default.
- W1483014538 countsByYear W14830145382016 @default.
- W1483014538 countsByYear W14830145382017 @default.
- W1483014538 countsByYear W14830145382018 @default.
- W1483014538 countsByYear W14830145382019 @default.
- W1483014538 countsByYear W14830145382020 @default.
- W1483014538 countsByYear W14830145382021 @default.
- W1483014538 countsByYear W14830145382022 @default.
- W1483014538 countsByYear W14830145382023 @default.
- W1483014538 crossrefType "journal-article" @default.
- W1483014538 hasAuthorship W1483014538A5033136225 @default.
- W1483014538 hasAuthorship W1483014538A5033846884 @default.
- W1483014538 hasAuthorship W1483014538A5050563694 @default.
- W1483014538 hasAuthorship W1483014538A5054650769 @default.
- W1483014538 hasAuthorship W1483014538A5067271160 @default.
- W1483014538 hasAuthorship W1483014538A5088251604 @default.
- W1483014538 hasConcept C126322002 @default.
- W1483014538 hasConcept C185592680 @default.
- W1483014538 hasConcept C203014093 @default.
- W1483014538 hasConcept C2777015399 @default.
- W1483014538 hasConcept C2778261982 @default.
- W1483014538 hasConcept C2779216453 @default.
- W1483014538 hasConcept C2780434524 @default.
- W1483014538 hasConcept C2781362458 @default.
- W1483014538 hasConcept C2993802102 @default.
- W1483014538 hasConcept C54173615 @default.
- W1483014538 hasConcept C71924100 @default.
- W1483014538 hasConcept C89560881 @default.
- W1483014538 hasConcept C98274493 @default.
- W1483014538 hasConceptScore W1483014538C126322002 @default.
- W1483014538 hasConceptScore W1483014538C185592680 @default.
- W1483014538 hasConceptScore W1483014538C203014093 @default.
- W1483014538 hasConceptScore W1483014538C2777015399 @default.
- W1483014538 hasConceptScore W1483014538C2778261982 @default.
- W1483014538 hasConceptScore W1483014538C2779216453 @default.
- W1483014538 hasConceptScore W1483014538C2780434524 @default.
- W1483014538 hasConceptScore W1483014538C2781362458 @default.
- W1483014538 hasConceptScore W1483014538C2993802102 @default.
- W1483014538 hasConceptScore W1483014538C54173615 @default.
- W1483014538 hasConceptScore W1483014538C71924100 @default.
- W1483014538 hasConceptScore W1483014538C89560881 @default.
- W1483014538 hasConceptScore W1483014538C98274493 @default.
- W1483014538 hasIssue "7" @default.
- W1483014538 hasLocation W14830145381 @default.
- W1483014538 hasLocation W14830145382 @default.
- W1483014538 hasOpenAccess W1483014538 @default.
- W1483014538 hasPrimaryLocation W14830145381 @default.
- W1483014538 hasRelatedWork W2029341269 @default.
- W1483014538 hasRelatedWork W2090080882 @default.
- W1483014538 hasRelatedWork W2110223924 @default.
- W1483014538 hasRelatedWork W2204777113 @default.
- W1483014538 hasRelatedWork W2335674401 @default.
- W1483014538 hasRelatedWork W2348943860 @default.
- W1483014538 hasRelatedWork W2367347897 @default.
- W1483014538 hasRelatedWork W2790631696 @default.
- W1483014538 hasRelatedWork W2811413127 @default.
- W1483014538 hasRelatedWork W3092299598 @default.
- W1483014538 hasVolume "38" @default.
- W1483014538 isParatext "false" @default.
- W1483014538 isRetracted "false" @default.
- W1483014538 magId "1483014538" @default.
- W1483014538 workType "article" @default.