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- W1483014934 abstract "Vitamin B12 is a required coenzyme for homocysteine remethylation, essential for the generation of S-adenosylmethionine, the source of methyl groups for DNA methylation. The objective of this study was to assess the association of low vitamin B12 status on global DNA methylation in reproductive age Chinese women. Global DNA methylation was assessed in two groups of women whose plasma vitamin B12 concentration was either deficient (<148 pmol/L) (n=24) or normal (>148 pmol/L)(n=128). To correct for the possible effects of RBC folate on DNA methylation, a subset (n= 24) of the vitamin B12 normal subjects were further matched for RBC folate concentration with the vitamin B12 deficient subjects. DNA methylation was expressed as a percent of methylated cytosines (as measured by a novel LC-MS/MS assay). The mean±SD % methylcytosine for the B12-deficient group (3.51±0.57) was lower (p<0.001) than the total normal group (4.42± 0.18), and the RBC folate-matched group (4.40±0.17). These data suggest that impaired vitamin B12 status might reduce global DNA methylation and provide a rationale for future investigations. This work was supported by a collaborative CDC agreement and the GCRC Grant # MO1-RR00082." @default.
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- W1483014934 date "2008-03-01" @default.
- W1483014934 modified "2023-09-26" @default.
- W1483014934 title "Low vitamin B12 status is negatively associated with global DNA methylation in young Chinese women" @default.
- W1483014934 doi "https://doi.org/10.1096/fasebj.22.1_supplement.689.8" @default.
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