Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483156031> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1483156031 endingPage "513" @default.
- W1483156031 startingPage "505" @default.
- W1483156031 abstract "Purpose: To investigate the specific antitumor responses against autologous hepatocellular carcinoma (HCC) cells of dendritic cells (DCs) fused with allogeneic HCC cell line, and evaluated the feasibility of BEL7402 as an alternative strategy to deliver shared HCC antigens to DCs. Methods: Previous studies demonstrated fusions of patient-derived DCs and autologous tumor cells could induce T-cell responses against autologous tumors. These fusion cells require patient-derived tumor cells, which are not, however, always available. Here, we report the fusing of autologous DCs with allogeneic HCC cell line to induced cytotoxic T-lymphocyte (CTL) response against autologous HCC cells compare with autologous tumor cells. Results: These DC/ BEL7402 fusion cells co-expressed tumor-associated antigens and DC-derived costimulatory and major histocompatibility complex molecules. Both CD4+ and CD8 T+ cells were activated by the fusion cells as demonstrated by the proliferation of T-cells, the production of cytokines and the simultaneous induction of specific CTL responses. Significantly, CTL induced by dendritic cell/allogeneic BEL7402 fusion cells were able to kill autologous HCC cells by human leukocyte antigen-A2 restricted mechanisms. The results did not show significant difference between DC fusion with autologous hepatocellular carcinoma cells and DC fusion with allogeneic hepatocellular carcinoma cell line. Conclusions: The fusion of allogeneic HCC cell line and autologous DCs may have applications in antitumor immunotherapy through cross-priming against shared tumor antigens and may provide a platform for adoptive immunotherapy." @default.
- W1483156031 created "2016-06-24" @default.
- W1483156031 creator A5010074837 @default.
- W1483156031 creator A5039737834 @default.
- W1483156031 creator A5063441337 @default.
- W1483156031 creator A5084351298 @default.
- W1483156031 date "2010-03-30" @default.
- W1483156031 modified "2023-10-18" @default.
- W1483156031 title "Dendritic cells fused with allogeneic hepatocellular carcinoma cell line compared with fused autologous tumor cells as hepatocellular carcinoma vaccines" @default.
- W1483156031 cites W1854615253 @default.
- W1483156031 cites W1964416857 @default.
- W1483156031 cites W1972625800 @default.
- W1483156031 cites W1990592566 @default.
- W1483156031 cites W1993031986 @default.
- W1483156031 cites W2004217316 @default.
- W1483156031 cites W2020447502 @default.
- W1483156031 cites W2025485742 @default.
- W1483156031 cites W2029704407 @default.
- W1483156031 cites W2032702007 @default.
- W1483156031 cites W2035046853 @default.
- W1483156031 cites W2061062253 @default.
- W1483156031 cites W2068340293 @default.
- W1483156031 cites W2074184139 @default.
- W1483156031 cites W2076818433 @default.
- W1483156031 cites W2082801423 @default.
- W1483156031 cites W2094857166 @default.
- W1483156031 cites W2118330797 @default.
- W1483156031 cites W2127468351 @default.
- W1483156031 cites W2142504949 @default.
- W1483156031 cites W2147771351 @default.
- W1483156031 cites W2169700552 @default.
- W1483156031 cites W2394610429 @default.
- W1483156031 doi "https://doi.org/10.1111/j.1872-034x.2010.00625.x" @default.
- W1483156031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20374301" @default.
- W1483156031 hasPublicationYear "2010" @default.
- W1483156031 type Work @default.
- W1483156031 sameAs 1483156031 @default.
- W1483156031 citedByCount "13" @default.
- W1483156031 countsByYear W14831560312012 @default.
- W1483156031 countsByYear W14831560312014 @default.
- W1483156031 countsByYear W14831560312016 @default.
- W1483156031 countsByYear W14831560312018 @default.
- W1483156031 countsByYear W14831560312021 @default.
- W1483156031 crossrefType "journal-article" @default.
- W1483156031 hasAuthorship W1483156031A5010074837 @default.
- W1483156031 hasAuthorship W1483156031A5039737834 @default.
- W1483156031 hasAuthorship W1483156031A5063441337 @default.
- W1483156031 hasAuthorship W1483156031A5084351298 @default.
- W1483156031 hasConcept C147483822 @default.
- W1483156031 hasConcept C147969180 @default.
- W1483156031 hasConcept C154317977 @default.
- W1483156031 hasConcept C167672396 @default.
- W1483156031 hasConcept C202751555 @default.
- W1483156031 hasConcept C203014093 @default.
- W1483156031 hasConcept C2776090121 @default.
- W1483156031 hasConcept C2777701055 @default.
- W1483156031 hasConcept C2778019345 @default.
- W1483156031 hasConcept C2778170410 @default.
- W1483156031 hasConcept C502942594 @default.
- W1483156031 hasConcept C55493867 @default.
- W1483156031 hasConcept C71924100 @default.
- W1483156031 hasConcept C86803240 @default.
- W1483156031 hasConcept C8891405 @default.
- W1483156031 hasConceptScore W1483156031C147483822 @default.
- W1483156031 hasConceptScore W1483156031C147969180 @default.
- W1483156031 hasConceptScore W1483156031C154317977 @default.
- W1483156031 hasConceptScore W1483156031C167672396 @default.
- W1483156031 hasConceptScore W1483156031C202751555 @default.
- W1483156031 hasConceptScore W1483156031C203014093 @default.
- W1483156031 hasConceptScore W1483156031C2776090121 @default.
- W1483156031 hasConceptScore W1483156031C2777701055 @default.
- W1483156031 hasConceptScore W1483156031C2778019345 @default.
- W1483156031 hasConceptScore W1483156031C2778170410 @default.
- W1483156031 hasConceptScore W1483156031C502942594 @default.
- W1483156031 hasConceptScore W1483156031C55493867 @default.
- W1483156031 hasConceptScore W1483156031C71924100 @default.
- W1483156031 hasConceptScore W1483156031C86803240 @default.
- W1483156031 hasConceptScore W1483156031C8891405 @default.
- W1483156031 hasIssue "5" @default.
- W1483156031 hasLocation W14831560311 @default.
- W1483156031 hasLocation W14831560312 @default.
- W1483156031 hasOpenAccess W1483156031 @default.
- W1483156031 hasPrimaryLocation W14831560311 @default.
- W1483156031 hasRelatedWork W1513178816 @default.
- W1483156031 hasRelatedWork W1992915380 @default.
- W1483156031 hasRelatedWork W2015747966 @default.
- W1483156031 hasRelatedWork W2018916009 @default.
- W1483156031 hasRelatedWork W2023919916 @default.
- W1483156031 hasRelatedWork W2047295876 @default.
- W1483156031 hasRelatedWork W2050020144 @default.
- W1483156031 hasRelatedWork W2071054957 @default.
- W1483156031 hasRelatedWork W2162173143 @default.
- W1483156031 hasRelatedWork W2387430262 @default.
- W1483156031 hasVolume "40" @default.
- W1483156031 isParatext "false" @default.
- W1483156031 isRetracted "false" @default.
- W1483156031 magId "1483156031" @default.
- W1483156031 workType "article" @default.