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- W1483200189 abstract "Biliary atresia (BA) is the most common cause of cholestasis during infancy for which an etiology remains undetermined. Patients require hepatic portoenterostomy within the first 2-3 months of life in order to restore bile flow from the liver into the intestinal tract. Even with successful surgery, in most patients the disease advances to end-stage cirrhosis due to the progressive destruction of bile ducts, and requires liver transplantation in order for long term survival to be viable (Mack & Sokol, 2005). Without a better understanding of the etiology and pathogenesis of the progressive cholangitic mechanisms in BA, improvement in the prognosis of non-transplantation patients should not be expected. Despite the importance of understanding these underlying mechanisms, research of BA has been hindered by the lack of a suitable animal model." @default.
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- W1483200189 date "2012-02-10" @default.
- W1483200189 modified "2023-09-23" @default.
- W1483200189 title "How Do Lampreys Avoid Cholestasis After Bile Duct Degeneration?" @default.
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- W1483200189 doi "https://doi.org/10.5772/35813" @default.
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