Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483209295> ?p ?o ?g. }
- W1483209295 endingPage "15" @default.
- W1483209295 startingPage "1" @default.
- W1483209295 abstract "Microglia-induced maladaptive plasticity is being recognized as a major cause of deleterious self-sustaining pathological processes that occur in neurodegenerative and neuroinflammatory diseases. Microglia, the primary homeostatic guardian of the central nervous system, exert critical functions both during development, in neural circuit reshaping, and during adult life, in the brain physiological and pathological surveillance. This delicate critical role can be disrupted by neural, but also peripheral, noxious stimuli that can prime microglia to become overreactive to a second noxious stimulus or worsen underlying pathological processes. Among regulators of microglia, neuropeptides can play a major role. Their receptors are widely expressed in microglial cells and neuropeptide challenge can potently influence microglial activity in vitro . More relevantly, this regulator activity has been assessed also in vivo , in experimental models of brain diseases. Neuropeptide action in the central nervous system has been associated with beneficial effects in neurodegenerative and neuroinflammatory pathological experimental models. This review describes some of the mechanisms of the microglia maladaptive plasticity in vivo and how neuropeptide activity can represent a useful therapeutical target in a variety of human brain pathologies." @default.
- W1483209295 created "2016-06-24" @default.
- W1483209295 creator A5005988178 @default.
- W1483209295 creator A5015833316 @default.
- W1483209295 creator A5043092838 @default.
- W1483209295 date "2015-01-01" @default.
- W1483209295 modified "2023-10-17" @default.
- W1483209295 title "Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides<i>In Vivo</i>" @default.
- W1483209295 cites W1487226011 @default.
- W1483209295 cites W1490818157 @default.
- W1483209295 cites W1526723238 @default.
- W1483209295 cites W1621058827 @default.
- W1483209295 cites W1622777525 @default.
- W1483209295 cites W1777941326 @default.
- W1483209295 cites W1838179021 @default.
- W1483209295 cites W1886438078 @default.
- W1483209295 cites W1964041350 @default.
- W1483209295 cites W1964176710 @default.
- W1483209295 cites W1964831127 @default.
- W1483209295 cites W1966110212 @default.
- W1483209295 cites W1967918311 @default.
- W1483209295 cites W1971167579 @default.
- W1483209295 cites W1971799714 @default.
- W1483209295 cites W1972718929 @default.
- W1483209295 cites W1973342839 @default.
- W1483209295 cites W1975207029 @default.
- W1483209295 cites W1975724680 @default.
- W1483209295 cites W1979028442 @default.
- W1483209295 cites W1979067492 @default.
- W1483209295 cites W1979454766 @default.
- W1483209295 cites W1980608200 @default.
- W1483209295 cites W1980661152 @default.
- W1483209295 cites W1980789245 @default.
- W1483209295 cites W1982844086 @default.
- W1483209295 cites W1987592276 @default.
- W1483209295 cites W1991002102 @default.
- W1483209295 cites W1992676736 @default.
- W1483209295 cites W1993753481 @default.
- W1483209295 cites W1996024251 @default.
- W1483209295 cites W1996641984 @default.
- W1483209295 cites W1997399782 @default.
- W1483209295 cites W1997962428 @default.
- W1483209295 cites W1998105826 @default.
- W1483209295 cites W2000196607 @default.
- W1483209295 cites W2001650386 @default.
- W1483209295 cites W2001856777 @default.
- W1483209295 cites W2002174378 @default.
- W1483209295 cites W2002442267 @default.
- W1483209295 cites W2004349171 @default.
- W1483209295 cites W2004488368 @default.
- W1483209295 cites W2004651512 @default.
- W1483209295 cites W2004678176 @default.
- W1483209295 cites W2004973774 @default.
- W1483209295 cites W2006839633 @default.
- W1483209295 cites W2007102205 @default.
- W1483209295 cites W2008467615 @default.
- W1483209295 cites W2009094217 @default.
- W1483209295 cites W2009357776 @default.
- W1483209295 cites W2016154943 @default.
- W1483209295 cites W2016964103 @default.
- W1483209295 cites W2017054975 @default.
- W1483209295 cites W2018016797 @default.
- W1483209295 cites W2019826512 @default.
- W1483209295 cites W2019845348 @default.
- W1483209295 cites W2022206129 @default.
- W1483209295 cites W2025496772 @default.
- W1483209295 cites W2026517317 @default.
- W1483209295 cites W2029603032 @default.
- W1483209295 cites W2029940067 @default.
- W1483209295 cites W2029991969 @default.
- W1483209295 cites W2030473266 @default.
- W1483209295 cites W2030955628 @default.
- W1483209295 cites W2031080113 @default.
- W1483209295 cites W2033617297 @default.
- W1483209295 cites W2034387476 @default.
- W1483209295 cites W2035299031 @default.
- W1483209295 cites W2036715358 @default.
- W1483209295 cites W2038440451 @default.
- W1483209295 cites W2038863919 @default.
- W1483209295 cites W2039578759 @default.
- W1483209295 cites W2040058024 @default.
- W1483209295 cites W2040166628 @default.
- W1483209295 cites W2042965197 @default.
- W1483209295 cites W2043020388 @default.
- W1483209295 cites W2043354554 @default.
- W1483209295 cites W2044736401 @default.
- W1483209295 cites W2046390054 @default.
- W1483209295 cites W2047371562 @default.
- W1483209295 cites W2047391965 @default.
- W1483209295 cites W2048515770 @default.
- W1483209295 cites W2049198952 @default.
- W1483209295 cites W2050275256 @default.
- W1483209295 cites W2050996473 @default.
- W1483209295 cites W2051504363 @default.
- W1483209295 cites W2052157422 @default.
- W1483209295 cites W2052442132 @default.
- W1483209295 cites W2052770514 @default.
- W1483209295 cites W2055682254 @default.