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- W1483251018 abstract "The bacterium Actinobacillus actinomycetemcomitans has been implicated in the pathogenesis of juvenile periodontitis as the etiologic agent on the basis of several lines of circumstantial evidence. A matter of extensive debate is whether A. actinomycetemcomitans is an exogenous contagious pathogen or an opportunistic pathogen that resides in the normal oral microflora. Here we show evidence of a single clone of A. actinomycetemcomitans isolated from multiple patients with juvenile periodontitis in members of families of African origin living in geographically widespread areas. The clone is characterized by a 530-bp deletion in the leukotoxin gene operon, resulting in a significantly increased production of leukotoxin." @default.
- W1483251018 created "2016-06-24" @default.
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- W1483251018 date "1996-06-01" @default.
- W1483251018 modified "2023-10-13" @default.
- W1483251018 title "Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin" @default.
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- W1483251018 doi "https://doi.org/10.1128/jcm.34.6.1576-1578.1996" @default.
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