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- W1483259781 abstract "The cytotoxic effects on Ehrlich ascites tumor cells of a large variety of compounds structurally related to maleuric acid (N-carbamylmaleamic acid) have been studied. The most effective compounds of this series were ethylenebis(maleurate), and the methyl, β-hydroxyethyl, allyl, 2-chloroethyl, isopropyl, and propargyl esters of maleuric acid (MA), all producing pyknotic chromatin masses as well as severe cytoplasmic blebbing and mitotic abnormalities at all stages of mitosis. Structural requirements for activity in this series of compounds are discussed. The effective esters destroyed the integrity of the spindle fibers and were effective in preventing the entry of preprophase cells into mitosis. Glutathione administered simultaneously counteracted the cytotoxic effects of the above effective compounds." @default.
- W1483259781 created "2016-06-24" @default.
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- W1483259781 date "1963-02-01" @default.
- W1483259781 modified "2023-09-23" @default.
- W1483259781 title "Cytotoxic effects of maleuric acid and the structurally related compounds on Ehrlich ascites tumor cells." @default.
- W1483259781 cites W1549503698 @default.
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- W1483259781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13939761" @default.
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