FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483261591> ?p ?o ?g. }

• W1483261591 endingPage "55" @default.
• W1483261591 startingPage "49" @default.
• W1483261591 abstract "Abstract The existing ideas about the ketorolac mechanism of analgetic potency are associated with its effect on COX isoenzymes and its significant potency needs to be explained more completely. Its impact on vanilloid receptors 1 (TRPV1) can also be an effective mechanism of analgetic action. We have evaluated the analgetic potential of ketorolac on the basis of its influence on TRPV1. It is known that Tyr511 and Ser512 amino acids are active central components of TRPV1. Thereby the synthesis of the dipeptide Tyr-Ser has been conducted as a model of the TRPV1 active centre. In our model test, using spectrofluorometry, the formation of intermolecular complexes was shown: “ketorolac - Tyr-Ser” and “capsaicin - Tyr-Ser” at stability constants Kr=0.53 • 10 -4 L/mol; K kor = 0.998 and Kr =0.3 • 10 -4 L/mol; K kor =0.998, respectively. Verification of the data was proved in experiments in vitro (the preparation of portal vein) and in vivo (Tail-flick model), with the TRPV1 agonist and antagonist. On portal vein, it was established (from initial level) by Krebs solution that the range of relaxation of smooth muscles of the portal vein (SM) was as follows at the concentration of capsaicin 0.1 μmol/L +30.3%±5.3%, capsazepine 0.5 μmol/L -3.2±2.7% and ketorolac 1.0 μmol/L -60.0±7.0%. In the experiment, at the above mentioned doses of ketorolac on the background of the action of the capsaicin (capsazepine), the range of relaxation of smooth muscles (SM) of the portal vein was -59.3±5.0% and -63.0±6.0% respectively testifying to the fact that the effect of capsaicinoids was neutralised by ketorolac. On the Tail-flick model, an atypical potentiation of the ketorolac antinociception at simultaneous use with the capsaicin was shown. The obtained data allow suggesting that TRPV1 can activate the ketorolac antinociceptive effects." @default.
• W1483261591 created "2016-06-24" @default.
• W1483261591 creator A5039339580 @default.
• W1483261591 creator A5052656124 @default.
• W1483261591 creator A5056445141 @default.
• W1483261591 creator A5056456994 @default.
• W1483261591 creator A5075634712 @default.
• W1483261591 date "2013-12-01" @default.
• W1483261591 modified "2023-09-27" @default.
• W1483261591 title "Involvement of the vanilloid receptor 1 in the mechanism of analgetic effect of ketorolac" @default.
• W1483261591 cites W1563676191 @default.
• W1483261591 cites W1765604498 @default.
• W1483261591 cites W1977748966 @default.
• W1483261591 cites W1990649212 @default.
• W1483261591 cites W2037382867 @default.
• W1483261591 cites W2072056062 @default.
• W1483261591 cites W2073864577 @default.
• W1483261591 cites W2092762650 @default.
• W1483261591 cites W2108600635 @default.
• W1483261591 cites W2113768972 @default.
• W1483261591 cites W2119214584 @default.
• W1483261591 cites W2155063211 @default.
• W1483261591 cites W2170691605 @default.
• W1483261591 cites W3133563286 @default.
• W1483261591 doi "https://doi.org/10.2478/afpuc-2013-0016" @default.
• W1483261591 hasPublicationYear "2013" @default.
• W1483261591 type Work @default.
• W1483261591 sameAs 1483261591 @default.
• W1483261591 citedByCount "0" @default.
• W1483261591 crossrefType "journal-article" @default.
• W1483261591 hasAuthorship W1483261591A5039339580 @default.
• W1483261591 hasAuthorship W1483261591A5052656124 @default.
• W1483261591 hasAuthorship W1483261591A5056445141 @default.
• W1483261591 hasAuthorship W1483261591A5056456994 @default.
• W1483261591 hasAuthorship W1483261591A5075634712 @default.
• W1483261591 hasBestOaLocation W14832615911 @default.
• W1483261591 hasConcept C150903083 @default.
• W1483261591 hasConcept C155164980 @default.
• W1483261591 hasConcept C160145004 @default.
• W1483261591 hasConcept C170493617 @default.
• W1483261591 hasConcept C185592680 @default.
• W1483261591 hasConcept C202751555 @default.
• W1483261591 hasConcept C207001950 @default.
• W1483261591 hasConcept C2776120743 @default.
• W1483261591 hasConcept C2776885963 @default.
• W1483261591 hasConcept C2778446825 @default.
• W1483261591 hasConcept C2778938600 @default.
• W1483261591 hasConcept C2780051329 @default.
• W1483261591 hasConcept C2780071552 @default.
• W1483261591 hasConcept C2780820201 @default.
• W1483261591 hasConcept C55493867 @default.
• W1483261591 hasConcept C57992300 @default.
• W1483261591 hasConcept C71240020 @default.
• W1483261591 hasConcept C71924100 @default.
• W1483261591 hasConcept C86803240 @default.
• W1483261591 hasConcept C98274493 @default.
• W1483261591 hasConceptScore W1483261591C150903083 @default.
• W1483261591 hasConceptScore W1483261591C155164980 @default.
• W1483261591 hasConceptScore W1483261591C160145004 @default.
• W1483261591 hasConceptScore W1483261591C170493617 @default.
• W1483261591 hasConceptScore W1483261591C185592680 @default.
• W1483261591 hasConceptScore W1483261591C202751555 @default.
• W1483261591 hasConceptScore W1483261591C207001950 @default.
• W1483261591 hasConceptScore W1483261591C2776120743 @default.
• W1483261591 hasConceptScore W1483261591C2776885963 @default.
• W1483261591 hasConceptScore W1483261591C2778446825 @default.
• W1483261591 hasConceptScore W1483261591C2778938600 @default.
• W1483261591 hasConceptScore W1483261591C2780051329 @default.
• W1483261591 hasConceptScore W1483261591C2780071552 @default.
• W1483261591 hasConceptScore W1483261591C2780820201 @default.
• W1483261591 hasConceptScore W1483261591C55493867 @default.
• W1483261591 hasConceptScore W1483261591C57992300 @default.
• W1483261591 hasConceptScore W1483261591C71240020 @default.
• W1483261591 hasConceptScore W1483261591C71924100 @default.
• W1483261591 hasConceptScore W1483261591C86803240 @default.
• W1483261591 hasConceptScore W1483261591C98274493 @default.
• W1483261591 hasIssue "2" @default.
• W1483261591 hasLocation W14832615911 @default.
• W1483261591 hasOpenAccess W1483261591 @default.
• W1483261591 hasPrimaryLocation W14832615911 @default.
• W1483261591 hasRelatedWork W1963644224 @default.
• W1483261591 hasRelatedWork W2005358668 @default.
• W1483261591 hasRelatedWork W2090426373 @default.
• W1483261591 hasRelatedWork W2093617388 @default.
• W1483261591 hasRelatedWork W2101091785 @default.
• W1483261591 hasRelatedWork W2106201634 @default.
• W1483261591 hasRelatedWork W2127780645 @default.
• W1483261591 hasRelatedWork W2131182476 @default.
• W1483261591 hasRelatedWork W2154369124 @default.
• W1483261591 hasRelatedWork W2168322600 @default.
• W1483261591 hasRelatedWork W2224011138 @default.
• W1483261591 hasRelatedWork W2264973177 @default.
• W1483261591 hasRelatedWork W2410783293 @default.
• W1483261591 hasRelatedWork W2886650102 @default.
• W1483261591 hasRelatedWork W2253824307 @default.
• W1483261591 hasVolume "60" @default.
• W1483261591 isParatext "false" @default.
• W1483261591 isRetracted "false" @default.

• next