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• W1483508760 endingPage "213" @default.
• W1483508760 startingPage "213" @default.
• W1483508760 abstract "Oligodendrogliomas represent the third most common type of glioma, comprising 4%-15% of all gliomas and can be classified by degree of malignancy into grade II and grade III, according to WHO classification. Only 30% of oligodendroglial tumors have anaplastic characteristics. Anaplastic oligodendroglioma (AO) is often localized as a single lesion in the white matter and in the cortex, rarely in brainstem or spinal cord. The management of AO is deeply changed in the recent years. Maximal safe surgical resection followed by radiotherapy (RT) was considered as the standard of care since paramount findings regarding molecular aspects, in particular co-deletion of the short arm of chromosome 1 and the long arm of chromosome 19, revealed that these subsets of AO, benefit in terms of overall survival (OS) and progression-free survival (PFS), from the addition of chemotherapy to RT. Allelic losses of chromosomes 1p and 19q occur in 50%-70% of both low-grade and anaplastic tumors, representing a strong prognostic factor and a powerful predictor of prolonged survival. Several other molecular markers have potential clinical significance as IDH1 mutations, confirming the strong prognostic role for OS. Malignant brain tumors negatively impacts on patients' quality of life. Seizures, visual impairment, headache, and cognitive disorders can be present. Moreover, chemotherapy and RT have important side effects. For these reasons, health-related quality of life is becoming a topic of growing interest, investigating on physical, mental, emotional, and social well-being. Understanding the impact of medical treatment on health-related quality of life will probably have a growing effect both on health care strategies and on patients." @default.
• W1483508760 created "2016-06-24" @default.
• W1483508760 creator A5003615466 @default.
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• W1483508760 date "2015-07-01" @default.
• W1483508760 modified "2023-10-18" @default.
• W1483508760 title "Clinical management of grade III oligodendroglioma" @default.
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• W1483508760 doi "https://doi.org/10.2147/cmar.s56975" @default.
• W1483508760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4524382" @default.
• W1483508760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26251628" @default.
• W1483508760 hasPublicationYear "2015" @default.
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