FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483541096> ?p ?o ?g. }

• W1483541096 endingPage "180" @default.
• W1483541096 startingPage "143" @default.
• W1483541096 abstract "The chapter focuses on p53—that is, a cell cycle regulator activated by deoxyribonucleic acid (DNA) damage. Mutations in the p53 tumor-suppressor gene occur at high frequency in a large variety of human tumors. These mutations include deletions of the entire gene, leading to complete loss of p53 expression, and missense point mutations that give rise to mutant p53 proteins lacking wild-type (WT) p53 activity. The high frequency of p53 alterations in human cancer suggests that this gene plays a critical role in the normal control of cell growth. A number of biological and biochemical functions have now been ascribed to WT p53. Importantly, mutant p53 proteins derived from human tumors are defective in some of these functions, suggesting that such functions are relevant for p53-mediated growth control and tumor suppression. This chapter reviews some of the recent progress in the exciting p53 field and proposes a model for the activation of p53 in response to DNA damage. The expression of exogenous WT p53 in various transformed cells carrying mutant p53 or completely lacking p53 inhibits cell proliferation. Experiments using replication of viral DNA as a model system have indicated that p53 may fulfill a role in the control of DNA replication. The common association between the viral oncoproteins and p53 represents a remarkable case of convergent evolution and provides strong evidence that p53 is a critical cell cycle regulator. P53 is normally an unstable protein with a half-life of 15–30 min. As a result, its levels in normal cells are almost undetectable and probably insufficient to suppress growth." @default.
• W1483541096 created "2016-06-24" @default.
• W1483541096 creator A5080066181 @default.
• W1483541096 creator A5087783342 @default.
• W1483541096 date "1995-01-01" @default.
• W1483541096 modified "2023-10-03" @default.
• W1483541096 title "p53: A Cell Cycle Regulator Activated by DNA Damage" @default.
• W1483541096 cites W14359987 @default.
• W1483541096 cites W1444355571 @default.
• W1483541096 cites W1487724525 @default.
• W1483541096 cites W1510257230 @default.
• W1483541096 cites W1525669528 @default.
• W1483541096 cites W1525939857 @default.
• W1483541096 cites W1545495395 @default.
• W1483541096 cites W1547769073 @default.
• W1483541096 cites W1550656265 @default.
• W1483541096 cites W1554072136 @default.
• W1483541096 cites W1565339590 @default.
• W1483541096 cites W1574489576 @default.
• W1483541096 cites W1576330810 @default.
• W1483541096 cites W1591281137 @default.
• W1483541096 cites W159325311 @default.
• W1483541096 cites W1636550642 @default.
• W1483541096 cites W1659382355 @default.
• W1483541096 cites W1674633125 @default.
• W1483541096 cites W168561149 @default.
• W1483541096 cites W172347017 @default.
• W1483541096 cites W174785446 @default.
• W1483541096 cites W1767560565 @default.
• W1483541096 cites W1768423394 @default.
• W1483541096 cites W1809276377 @default.
• W1483541096 cites W1822460389 @default.
• W1483541096 cites W1823168351 @default.
• W1483541096 cites W1824125043 @default.
• W1483541096 cites W1831428880 @default.
• W1483541096 cites W1839476071 @default.
• W1483541096 cites W1842375597 @default.
• W1483541096 cites W1861504067 @default.
• W1483541096 cites W1861749169 @default.
• W1483541096 cites W1903324674 @default.
• W1483541096 cites W1923756169 @default.
• W1483541096 cites W1926834804 @default.
• W1483541096 cites W1927337580 @default.
• W1483541096 cites W1965173366 @default.
• W1483541096 cites W1966630774 @default.
• W1483541096 cites W1969881374 @default.
• W1483541096 cites W1974355172 @default.
• W1483541096 cites W1975122645 @default.
• W1483541096 cites W1976971420 @default.
• W1483541096 cites W1977145510 @default.
• W1483541096 cites W1977686001 @default.
• W1483541096 cites W1980066350 @default.
• W1483541096 cites W1980655006 @default.
• W1483541096 cites W1982259691 @default.
• W1483541096 cites W1983971803 @default.
• W1483541096 cites W1986179131 @default.
• W1483541096 cites W1987536971 @default.
• W1483541096 cites W1988112194 @default.
• W1483541096 cites W1988346665 @default.
• W1483541096 cites W1988756673 @default.
• W1483541096 cites W1989887575 @default.
• W1483541096 cites W1992817421 @default.
• W1483541096 cites W1992864942 @default.
• W1483541096 cites W1993831923 @default.
• W1483541096 cites W1995095999 @default.
• W1483541096 cites W1995806503 @default.
• W1483541096 cites W1995856480 @default.
• W1483541096 cites W1998008917 @default.
• W1483541096 cites W1999632568 @default.
• W1483541096 cites W2003236156 @default.
• W1483541096 cites W2003282728 @default.
• W1483541096 cites W2003962192 @default.
• W1483541096 cites W2005546492 @default.
• W1483541096 cites W2007772649 @default.
• W1483541096 cites W2009745999 @default.
• W1483541096 cites W2012053348 @default.
• W1483541096 cites W2013136213 @default.
• W1483541096 cites W2013391301 @default.
• W1483541096 cites W2013752620 @default.
• W1483541096 cites W2015314126 @default.
• W1483541096 cites W2015519364 @default.
• W1483541096 cites W2016107093 @default.
• W1483541096 cites W2017293277 @default.
• W1483541096 cites W2018385269 @default.
• W1483541096 cites W2020916241 @default.
• W1483541096 cites W2023530705 @default.
• W1483541096 cites W2024894759 @default.
• W1483541096 cites W2028143623 @default.
• W1483541096 cites W2028143792 @default.
• W1483541096 cites W2029529223 @default.
• W1483541096 cites W2030283142 @default.
• W1483541096 cites W2032660991 @default.
• W1483541096 cites W2037670899 @default.
• W1483541096 cites W2039382131 @default.
• W1483541096 cites W2040159897 @default.
• W1483541096 cites W2042316019 @default.
• W1483541096 cites W2042425655 @default.
• W1483541096 cites W2043912950 @default.

• next