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- W1483576392 endingPage "884" @default.
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- W1483576392 abstract "Family C of human G‐protein‐coupled receptors (GPCRs) is constituted by eight metabotropic glutamate receptors, two γ‐aminobutyric acid type B (GABA B1–2 ) subunits forming the heterodimeric GABA B receptor, the calcium‐sensing receptor, three taste1 receptors (T1R1–3), a promiscuous L‐α‐amino acid receptor G‐protein‐coupled receptor family C, group 6, subtype A (GPRC6A) and seven orphan receptors. Aside from the orphan receptors, the family C GPCRs are dimeric receptors characterized by a large extracellular Venus flytrap domain which bind the endogenous agonists. Except from the GABA B1–2 and T1R2–3 receptor, all receptors are either activated or positively modulated by amino acids. In this review, we outline mutational, biophysical and structural studies which have elucidated the interaction of the amino acids with the Venus flytrap domains, molecular mechanisms of receptor selectivity and the initial steps in receptor activation." @default.
- W1483576392 created "2016-06-24" @default.
- W1483576392 creator A5004224346 @default.
- W1483576392 creator A5089455458 @default.
- W1483576392 date "2009-03-01" @default.
- W1483576392 modified "2023-10-16" @default.
- W1483576392 title "Molecular basis for amino acid sensing by family C G-protein-coupled receptors" @default.
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