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- W1483605266 abstract "Many methods have been used to identify T and B cells and their subtypes in terms of both physical attributes and function in a range of in vitro tests. The present report deals with an in vivo approach to the character of circulating lymphocytes from 10 patients with chronic lymphocytic leukemia (CLL) as compared to lymphoid cells from normal donors, using the Elkins graft versus host reaction (GVHR) assay in kidney and an assay involving injection of lymphoid cells in the external oblique abdominal muscle of immunosuppressed rats. GVHR in the muscle was assessed by (a) measuring diameter of the lesion, (b) examining histology of the injected site, and (c) determining uptake of [125I]deoxyuridine into DNA of proliferating cells. Results show that lymphocytes from normal donors elicit a GVHR in both kidney and muscle, producing characteristic invasion and destruction of the injected tissue, while CLL lymphocytes, even in large numbers, produce no response by any of the criteria in either tissue. CLL cells remain localized at the injection site without undergoing the changes of activation and proliferation. Results in the muscle parallel those in the kidney. The muscle assay requires fewer cells and permits a larger number of assessments per animal. Potentially it can be applied to classification of lymphoreticular disorders and immunodeficiency states." @default.
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- W1483605266 date "1977-01-01" @default.
- W1483605266 modified "2023-09-24" @default.
- W1483605266 title "Studies on the local graft versus host reactivity of normal and chronic lymphocytic leukemia lymphocytes" @default.
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- W1483605266 doi "https://doi.org/10.1016/0090-1229(77)90026-5" @default.
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