FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483633293> ?p ?o ?g. }

• W1483633293 endingPage "1820" @default.
• W1483633293 startingPage "1809" @default.
• W1483633293 abstract "Metastatic breast cancer cells are frequently associated with osteoclast-mediated bone resorption, resulting in severe bone destruction and increased mortality in patients. Platycodin D (PD) isolated from Platycodon grandiflorum is a triterpenoid saponin with anti-cancer and anti-angiogenic potential.The in vivo activity was determined in mice with the intratibial injection of human metastatic breast cancer cells. Osteoclast formation and activity were detected using tartrate-resistant acid phosphatase staining and calcium phosphate-coated plates. The expression of osteoclastogenesis-inducing molecules was detected by RT-PCR and western blotting in RANKL-treated bone marrow macrophages (BMMs). Cell viability and DNA synthesis were measured with MTT and BrdU incorporation assays. The induction of apoptosis was estimated using TUNEL staining and a caspase-3 activity assay.The oral administration of PD inhibited MDA-MB-231 cell-induced osteolysis in an intratibial mouse model. PD treatment blocked RANKL-induced osteoclast formation by inhibiting the expression and nuclear translocation of NFATc1 and c-Fos in BMMs and consequently reduced osteoclast-mediated bone resorption. Furthermore, PD treatment induced apoptosis in osteoclasts and inhibited the growth of MDA-MB-231 cells.PD may block breast cancer-induced bone loss by suppressing the formation, activity, and survival of osteoclasts, as well as the growth of metastatic breast cancer cells." @default.
• W1483633293 created "2016-06-24" @default.
• W1483633293 creator A5005358084 @default.
• W1483633293 creator A5017775627 @default.
• W1483633293 creator A5018692831 @default.
• W1483633293 creator A5033031742 @default.
• W1483633293 creator A5036993764 @default.
• W1483633293 creator A5037838961 @default.
• W1483633293 creator A5047761858 @default.
• W1483633293 creator A5087539919 @default.
• W1483633293 creator A5090040816 @default.
• W1483633293 date "2015-01-01" @default.
• W1483633293 modified "2023-10-16" @default.
• W1483633293 title "Platycodin D Blocks Breast Cancer-Induced Bone Destruction by Inhibiting Osteoclastogenesis and the Growth of Breast Cancer Cells" @default.
• W1483633293 cites W1578495348 @default.
• W1483633293 cites W1745634660 @default.
• W1483633293 cites W188417689 @default.
• W1483633293 cites W1965535995 @default.
• W1483633293 cites W1965694039 @default.
• W1483633293 cites W1966662013 @default.
• W1483633293 cites W1979528991 @default.
• W1483633293 cites W1981411106 @default.
• W1483633293 cites W1984933848 @default.
• W1483633293 cites W1986666543 @default.
• W1483633293 cites W1987107938 @default.
• W1483633293 cites W1990037409 @default.
• W1483633293 cites W1990461795 @default.
• W1483633293 cites W1991235458 @default.
• W1483633293 cites W1993358064 @default.
• W1483633293 cites W1995391021 @default.
• W1483633293 cites W2000278808 @default.
• W1483633293 cites W2000894286 @default.
• W1483633293 cites W2005392579 @default.
• W1483633293 cites W2011993185 @default.
• W1483633293 cites W2013351930 @default.
• W1483633293 cites W2015006948 @default.
• W1483633293 cites W2017372504 @default.
• W1483633293 cites W2017462403 @default.
• W1483633293 cites W2017987164 @default.
• W1483633293 cites W2026988411 @default.
• W1483633293 cites W2028593879 @default.
• W1483633293 cites W2040605051 @default.
• W1483633293 cites W2049532865 @default.
• W1483633293 cites W2051140406 @default.
• W1483633293 cites W2057380855 @default.
• W1483633293 cites W2064346787 @default.
• W1483633293 cites W2069663504 @default.
• W1483633293 cites W2087324367 @default.
• W1483633293 cites W2093252878 @default.
• W1483633293 cites W2094321811 @default.
• W1483633293 cites W2097832852 @default.
• W1483633293 cites W2100662195 @default.
• W1483633293 cites W2104872826 @default.
• W1483633293 cites W2127932938 @default.
• W1483633293 cites W2129303830 @default.
• W1483633293 cites W2132311567 @default.
• W1483633293 cites W2136857252 @default.
• W1483633293 cites W2158903927 @default.
• W1483633293 cites W243224688 @default.
• W1483633293 cites W2474253747 @default.
• W1483633293 cites W4445544 @default.
• W1483633293 doi "https://doi.org/10.1159/000430152" @default.
• W1483633293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26184636" @default.
• W1483633293 hasPublicationYear "2015" @default.
• W1483633293 type Work @default.
• W1483633293 sameAs 1483633293 @default.
• W1483633293 citedByCount "17" @default.
• W1483633293 countsByYear W14836332932015 @default.
• W1483633293 countsByYear W14836332932016 @default.
• W1483633293 countsByYear W14836332932017 @default.
• W1483633293 countsByYear W14836332932018 @default.
• W1483633293 countsByYear W14836332932019 @default.
• W1483633293 countsByYear W14836332932020 @default.
• W1483633293 countsByYear W14836332932022 @default.
• W1483633293 countsByYear W14836332932023 @default.
• W1483633293 crossrefType "journal-article" @default.
• W1483633293 hasAuthorship W1483633293A5005358084 @default.
• W1483633293 hasAuthorship W1483633293A5017775627 @default.
• W1483633293 hasAuthorship W1483633293A5018692831 @default.
• W1483633293 hasAuthorship W1483633293A5033031742 @default.
• W1483633293 hasAuthorship W1483633293A5036993764 @default.
• W1483633293 hasAuthorship W1483633293A5037838961 @default.
• W1483633293 hasAuthorship W1483633293A5047761858 @default.
• W1483633293 hasAuthorship W1483633293A5087539919 @default.
• W1483633293 hasAuthorship W1483633293A5090040816 @default.
• W1483633293 hasBestOaLocation W14836332931 @default.
• W1483633293 hasConcept C121608353 @default.
• W1483633293 hasConcept C126322002 @default.
• W1483633293 hasConcept C141071460 @default.
• W1483633293 hasConcept C142724271 @default.
• W1483633293 hasConcept C170493617 @default.
• W1483633293 hasConcept C180675623 @default.
• W1483633293 hasConcept C185592680 @default.
• W1483633293 hasConcept C190283241 @default.
• W1483633293 hasConcept C202751555 @default.
• W1483633293 hasConcept C2776033226 @default.
• W1483633293 hasConcept C2779428903 @default.
• W1483633293 hasConcept C2781282405 @default.

• next