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- W1483708145 abstract "Abstract The transfer of galactose from labeled uridine diphosphogalactose to glucosylceramide and to galactosyl-glucosylceramide (lactosylceramide) was shown to occur in incubations with rat spleen, brain, kidney, liver, and bone marrow preparations. In all tissues examined, glucosylceramide stimulates the biosynthesis of lactosylceramide, and lactosylceramide stimulates the biosynthesis of galactosyl-galactosyl-glucosylceramide (triglycosylceramide). These biosynthetic reactions were characterized further in spleen, which contains endogenous levels of glucosylceramide and lactosylceramide of, respectively, 0.13 to 0.25 and 0.01 to 0.02 µmole per g of wet weight. The biosynthesis of lactosylceramide, previously shown with glucosylceramide and labeled UDP-galactose, was confirmed by its formation from radioactive glucosylceramide and unlabeled UDP-galactose. Triglycosylceramide was identified by its elution pattern from Florisil columns, its resistance to mild alkaline hydrolysis, the location of the radioactivity in galactose, and chromatography with triglycosylceramide standards in six solvent systems. The enzymatic activities involved in the biosynthesis of the two glycosphingolipids are both located in the microsomal fraction, are markedly stimulated by Mn++ and have the same optimal pH (6.1). However, they were differentiated from each other by their lability to heat, extent of inhibition by various sphingolipids, and stimulation by Mg++. They also appear different from the galactosyltransferase found in chicken brain (29) and rat spleen which catalyzes the formation of ganglioside Gm1 from UDP-galactose and Tay-Sachs' ganglioside." @default.
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- W1483708145 date "1969-10-01" @default.
- W1483708145 modified "2023-10-18" @default.
- W1483708145 title "Biosynthesis of Lactosylceramide and Triglycosylceramide by Galactosyltransferases from Rat Spleen" @default.
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- W1483708145 doi "https://doi.org/10.1016/s0021-9258(18)63642-7" @default.
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