FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1483817653> ?p ?o ?g. }

• W1483817653 abstract "Inflammation involves interactions amongst many different cell types as a defense mechanism of the body. Inflammation is also involved in cardiovascular disease (CVD). The role of long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) in modulating the inflammatory response has been proposed. The aim of these studies is to investigate the effects of modest intakes of n-3 PUFAs on CVD risk factors especially inflammatory markers, including soluble adhesion molecules, in adult humans with and without CVD and to identify the effects of selected fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on inflammatory responses, especially adhesion molecule expression in cultured human endothelial cells of different origin (fetal vs. adults; vein vs. artery). In the first in vivo study, healthy middle-aged men aged 35-60 years were randomized to 1.8 g/d EPA plus 0.23 g/d DHA (n = 9) or placebo oil (2.6 g/day medium-chain saturated fatty acids; n = 11) for 8 weeks. In a second in vivo study, patients awaiting carotid endarterectomy were randomised to 0.8 g/d EPA plus 0.67 g/d DHA (Omacor; n = 47) or olive oil (n = 53) as placebo for between 7 and 102 days until surgery. Supplementation with fish oil in healthy men resulted in a 363% increase in EPA and only a 13% increase in DHA in plasma phosphatidylcholine (PC). On the other hand, Omacor supplementation resulted in significantly increased EPA and DHA in plasma PC by 161% and 70%, respectively. In healthy subjects, there was very little effect of n-3 fatty acids on the risk factors measured (lipid profiles and inflammatory markers), apart from a reduction in plasma soluble intercellular molecule-1 (sICAM-1) concentration compared with placebo (P = 0.05). The change in plasma sICAM-1 concentration was significantly inversely associated with the change in DHA in plasma PC (r = -0.675; P = 0.001). Supplementation with Omacor, however, significantly decreased total plasma cholesterol, triacylglycerol (TAG) and LDL-cholesterol concentrations (P In the in vitro experiments the inflammatory stimulus lipopolysaccharide (LPS) up-regulated all three adhesion molecules studied at the protein (as assessed by ELISA) and the mRNA (as assessed by reverse transcription and real-time PCR) levels. VCAM-1 was affected by fatty acids to a greater extent than ICAM-1 or E-selectin. Amongst the fatty acids, DHA has the greatest and the most consistent effects on adhesion molecule protein expression. EPA was also a potent fatty acid inhibitor of adhesion molecule expression at the mRNA level. Some effects of stearic, oleic and arachidonic acids on adhesion molecules were also seen. The effects of fatty acids on the adhesion molecule expression were fatty acid, adhesion molecule and endothelial cell specific. The inhibitory effects of fatty acids were more pronounced in vein endothelial cells than arterial endothelial cells. The precise underlying mechanism on how fatty acids affect adhesion molecule expression remains to be clarified." @default.
• W1483817653 created "2016-06-24" @default.
• W1483817653 creator A5046803041 @default.
• W1483817653 date "2008-12-01" @default.
• W1483817653 modified "2023-09-26" @default.
• W1483817653 title "Effects of fatty acids on inflammatory markers studied in vivo and in vitro" @default.
• W1483817653 hasPublicationYear "2008" @default.
• W1483817653 type Work @default.
• W1483817653 sameAs 1483817653 @default.
• W1483817653 citedByCount "0" @default.
• W1483817653 crossrefType "dissertation" @default.
• W1483817653 hasAuthorship W1483817653A5046803041 @default.
• W1483817653 hasConcept C126322002 @default.
• W1483817653 hasConcept C134018914 @default.
• W1483817653 hasConcept C142724271 @default.
• W1483817653 hasConcept C150903083 @default.
• W1483817653 hasConcept C185592680 @default.
• W1483817653 hasConcept C19038510 @default.
• W1483817653 hasConcept C204787440 @default.
• W1483817653 hasConcept C207001950 @default.
• W1483817653 hasConcept C27081682 @default.
• W1483817653 hasConcept C2776091944 @default.
• W1483817653 hasConcept C2776330855 @default.
• W1483817653 hasConcept C2776914184 @default.
• W1483817653 hasConcept C2777171753 @default.
• W1483817653 hasConcept C2778206080 @default.
• W1483817653 hasConcept C2778918659 @default.
• W1483817653 hasConcept C2779946292 @default.
• W1483817653 hasConcept C2909208804 @default.
• W1483817653 hasConcept C41625074 @default.
• W1483817653 hasConcept C505870484 @default.
• W1483817653 hasConcept C543025807 @default.
• W1483817653 hasConcept C55493867 @default.
• W1483817653 hasConcept C71924100 @default.
• W1483817653 hasConcept C86803240 @default.
• W1483817653 hasConcept C98274493 @default.
• W1483817653 hasConceptScore W1483817653C126322002 @default.
• W1483817653 hasConceptScore W1483817653C134018914 @default.
• W1483817653 hasConceptScore W1483817653C142724271 @default.
• W1483817653 hasConceptScore W1483817653C150903083 @default.
• W1483817653 hasConceptScore W1483817653C185592680 @default.
• W1483817653 hasConceptScore W1483817653C19038510 @default.
• W1483817653 hasConceptScore W1483817653C204787440 @default.
• W1483817653 hasConceptScore W1483817653C207001950 @default.
• W1483817653 hasConceptScore W1483817653C27081682 @default.
• W1483817653 hasConceptScore W1483817653C2776091944 @default.
• W1483817653 hasConceptScore W1483817653C2776330855 @default.
• W1483817653 hasConceptScore W1483817653C2776914184 @default.
• W1483817653 hasConceptScore W1483817653C2777171753 @default.
• W1483817653 hasConceptScore W1483817653C2778206080 @default.
• W1483817653 hasConceptScore W1483817653C2778918659 @default.
• W1483817653 hasConceptScore W1483817653C2779946292 @default.
• W1483817653 hasConceptScore W1483817653C2909208804 @default.
• W1483817653 hasConceptScore W1483817653C41625074 @default.
• W1483817653 hasConceptScore W1483817653C505870484 @default.
• W1483817653 hasConceptScore W1483817653C543025807 @default.
• W1483817653 hasConceptScore W1483817653C55493867 @default.
• W1483817653 hasConceptScore W1483817653C71924100 @default.
• W1483817653 hasConceptScore W1483817653C86803240 @default.
• W1483817653 hasConceptScore W1483817653C98274493 @default.
• W1483817653 hasLocation W14838176531 @default.
• W1483817653 hasOpenAccess W1483817653 @default.
• W1483817653 hasPrimaryLocation W14838176531 @default.
• W1483817653 hasRelatedWork W1513639150 @default.
• W1483817653 hasRelatedWork W1643108421 @default.
• W1483817653 hasRelatedWork W1970020878 @default.
• W1483817653 hasRelatedWork W2014213964 @default.
• W1483817653 hasRelatedWork W2106876061 @default.
• W1483817653 hasRelatedWork W2108556371 @default.
• W1483817653 hasRelatedWork W2165433475 @default.
• W1483817653 hasRelatedWork W2292431568 @default.
• W1483817653 hasRelatedWork W2352501943 @default.
• W1483817653 hasRelatedWork W2372522171 @default.
• W1483817653 hasRelatedWork W2382149210 @default.
• W1483817653 hasRelatedWork W2560370855 @default.
• W1483817653 hasRelatedWork W2577073885 @default.
• W1483817653 hasRelatedWork W2592957529 @default.
• W1483817653 hasRelatedWork W2597527832 @default.
• W1483817653 hasRelatedWork W2922441820 @default.
• W1483817653 hasRelatedWork W2962615203 @default.
• W1483817653 hasRelatedWork W3035756746 @default.
• W1483817653 hasRelatedWork W3136850445 @default.
• W1483817653 hasRelatedWork W994341102 @default.
• W1483817653 isParatext "false" @default.
• W1483817653 isRetracted "false" @default.
• W1483817653 magId "1483817653" @default.
• W1483817653 workType "dissertation" @default.