Matches in SemOpenAlex for { <https://semopenalex.org/work/W148402662> ?p ?o ?g. }
- W148402662 endingPage "39" @default.
- W148402662 startingPage "32" @default.
- W148402662 abstract "The involvement of white blood cells in microvascular derangement as a cause of secondary brain damage following cerebral ischemia is reviewed. Relevant data from the literature are arranged in the chronological sequence of the microvascular derangement of the brain that occurs after cerebral arterial occlusion (as based on our own experimental observations). The inflammatory processes which appeared to be elicited by polymorphonuclear leukocytes (PMNL) in the ischemic region of the brain may begin with adhesion of PMNLs to endothelial cells, followed by blood-brain barrier disruption, transudation/exudation, edema, necrosis, and scar formation. Stimulated by cytokines released from damaged neurons and axons, two types of macrophages (ameboid and ramified) appear, increase in number in the ischemic lesion, and engulf the debris of dead neurons, degenerated axons. Further, macrophages may release cytokines which stimulate healing processes, such as astroglial proliferation and revascularization, and release neurotoxins which could gradually kill surviving neurons. Even under such circumstances, individual leukocytes/macrophages are well regulated by specific mediators/cytokines. An urgent task is thus to find ways of controlling these key mediators/cytokines to reduce the inflammatory process and the extent of neuronal death for attenuating the secondary brain damage, without altering their beneficial effects." @default.
- W148402662 created "2016-06-24" @default.
- W148402662 creator A5068342644 @default.
- W148402662 creator A5069099817 @default.
- W148402662 date "1996-01-01" @default.
- W148402662 modified "2023-09-25" @default.
- W148402662 title "Leukocytes, Macrophages and Secondary Brain Damage Following Cerebral Ischemia" @default.
- W148402662 cites W1964794794 @default.
- W148402662 cites W1973485097 @default.
- W148402662 cites W1977821697 @default.
- W148402662 cites W1978166151 @default.
- W148402662 cites W1980369396 @default.
- W148402662 cites W1981505979 @default.
- W148402662 cites W1990060262 @default.
- W148402662 cites W1998200062 @default.
- W148402662 cites W2004351423 @default.
- W148402662 cites W2006809781 @default.
- W148402662 cites W2017610845 @default.
- W148402662 cites W2020138738 @default.
- W148402662 cites W2023943992 @default.
- W148402662 cites W2025719022 @default.
- W148402662 cites W2026469557 @default.
- W148402662 cites W2033652918 @default.
- W148402662 cites W2040671393 @default.
- W148402662 cites W2046304556 @default.
- W148402662 cites W2050694917 @default.
- W148402662 cites W2052523166 @default.
- W148402662 cites W2058109644 @default.
- W148402662 cites W2063782042 @default.
- W148402662 cites W2065458959 @default.
- W148402662 cites W2066524488 @default.
- W148402662 cites W2067436359 @default.
- W148402662 cites W2068384471 @default.
- W148402662 cites W2076162707 @default.
- W148402662 cites W2077404136 @default.
- W148402662 cites W2080562431 @default.
- W148402662 cites W2085935734 @default.
- W148402662 cites W2105054347 @default.
- W148402662 cites W2131659895 @default.
- W148402662 cites W2139323441 @default.
- W148402662 cites W2142468953 @default.
- W148402662 cites W2151080594 @default.
- W148402662 cites W2152282715 @default.
- W148402662 cites W424946559 @default.
- W148402662 cites W67756506 @default.
- W148402662 doi "https://doi.org/10.1007/978-3-7091-9465-2_6" @default.
- W148402662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8780794" @default.
- W148402662 hasPublicationYear "1996" @default.
- W148402662 type Work @default.
- W148402662 sameAs 148402662 @default.
- W148402662 citedByCount "12" @default.
- W148402662 countsByYear W1484026622012 @default.
- W148402662 countsByYear W1484026622015 @default.
- W148402662 countsByYear W1484026622016 @default.
- W148402662 countsByYear W1484026622017 @default.
- W148402662 crossrefType "book-chapter" @default.
- W148402662 hasAuthorship W148402662A5068342644 @default.
- W148402662 hasAuthorship W148402662A5069099817 @default.
- W148402662 hasConcept C126322002 @default.
- W148402662 hasConcept C142724271 @default.
- W148402662 hasConcept C169760540 @default.
- W148402662 hasConcept C203014093 @default.
- W148402662 hasConcept C2776914184 @default.
- W148402662 hasConcept C2778402981 @default.
- W148402662 hasConcept C2778690821 @default.
- W148402662 hasConcept C2779830541 @default.
- W148402662 hasConcept C2781458332 @default.
- W148402662 hasConcept C3019162651 @default.
- W148402662 hasConcept C503630168 @default.
- W148402662 hasConcept C529278444 @default.
- W148402662 hasConcept C541997718 @default.
- W148402662 hasConcept C71924100 @default.
- W148402662 hasConcept C86803240 @default.
- W148402662 hasConceptScore W148402662C126322002 @default.
- W148402662 hasConceptScore W148402662C142724271 @default.
- W148402662 hasConceptScore W148402662C169760540 @default.
- W148402662 hasConceptScore W148402662C203014093 @default.
- W148402662 hasConceptScore W148402662C2776914184 @default.
- W148402662 hasConceptScore W148402662C2778402981 @default.
- W148402662 hasConceptScore W148402662C2778690821 @default.
- W148402662 hasConceptScore W148402662C2779830541 @default.
- W148402662 hasConceptScore W148402662C2781458332 @default.
- W148402662 hasConceptScore W148402662C3019162651 @default.
- W148402662 hasConceptScore W148402662C503630168 @default.
- W148402662 hasConceptScore W148402662C529278444 @default.
- W148402662 hasConceptScore W148402662C541997718 @default.
- W148402662 hasConceptScore W148402662C71924100 @default.
- W148402662 hasConceptScore W148402662C86803240 @default.
- W148402662 hasLocation W1484026621 @default.
- W148402662 hasLocation W1484026622 @default.
- W148402662 hasOpenAccess W148402662 @default.
- W148402662 hasPrimaryLocation W1484026621 @default.
- W148402662 hasRelatedWork W1021201883 @default.
- W148402662 hasRelatedWork W1964141786 @default.
- W148402662 hasRelatedWork W2128971541 @default.
- W148402662 hasRelatedWork W2129388376 @default.
- W148402662 hasRelatedWork W2139145606 @default.
- W148402662 hasRelatedWork W2378961392 @default.