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• W1484037209 abstract "This chapter focuses on the multilateral effects of methylglyoxal and discusses the biological significance and function of methylglyoxal with respect to metabolic pathways, regulation of enzyme activity and expression of the gene in some microorganisms. The production of S-D-lactoylglutathione, an intermediate of the glyoxalase system, and its physiological activity are described. There are insufficient data on the route by which glucose is metabolized to pyruvic acid in mutants, deficient in the enzymes, involved in glycolysis or in the glycolytic methylglyoxal pathway. Oxidative conversion of methylglyoxal to pyruvic acid is also not energy-generating. These routes are not an equivalent to glycolysis with respect to energy conservation. The complexity of the regulation of metabolism of methylglyoxal implies that the glycolytic methylglyoxal pathway is not only a detoxification system in cells, but also may have some significant functions in the characteristic properties of living systems—that is growth, proliferation, and differentiation. The chapter discusses the formation and metabolism of methylglyoxal, genes for metabolic enzymes of methylglyoxal in microorganisms, regulation of glyoxalase I activity in yeast, and S-D-lactoylglutathione." @default.
• W1484037209 created "2016-06-24" @default.
• W1484037209 creator A5007715914 @default.
• W1484037209 creator A5048930001 @default.
• W1484037209 date "1995-01-01" @default.
• W1484037209 modified "2023-10-15" @default.
• W1484037209 title "Methylglyoxal and Regulation of its Metabolism in Microorganisms" @default.
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