FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484040899> ?p ?o ?g. }

• W1484040899 endingPage "1428" @default.
• W1484040899 startingPage "1419" @default.
• W1484040899 abstract "Chronic administration to rats of the anticonvulsant drug, valproate, induced proliferation of liver peroxisomes and selectively increased the activity of the enzymes involved in β-oxidation in these organelles. In kidney cortex, only a moderate increase in enzyme activity could be recored. Valproate (1% w/w in the diet for 25 to 100 days) caused the appearance on electron micrographs of unusual tubular inclusions in the matrix of liver peroxisomes. SDS-PAGE analysis of purified peroxisomal fractions from treated rats demonstrated an increase in the content of five polypeptides; four of peroxisomal inclusions correspond to the accumulation of these polypeptides in the matrix of the organelle. An in vivo evaluation of the peroxisomal hydrogen peroxide production suggested that valproate itself or one of its metabolites is substrate for peroxisomal β-oxidation. This was confirmed by in vitro studies. Activation of valproate or its metabolites by liver acyl-CoA synthetase could be demonstrated, although it was 50 times slower than that of octanoate. This reaction further led to a small, but significant production of H2O2 by the action of peroxisomal acyl-CoA oxidase." @default.
• W1484040899 created "2016-06-24" @default.
• W1484040899 creator A5015036022 @default.
• W1484040899 creator A5043457314 @default.
• W1484040899 creator A5054258694 @default.
• W1484040899 creator A5070312706 @default.
• W1484040899 date "1991-05-01" @default.
• W1484040899 modified "2023-09-30" @default.
• W1484040899 title "Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney" @default.
• W1484040899 cites W1205458192 @default.
• W1484040899 cites W1528760252 @default.
• W1484040899 cites W1633034930 @default.
• W1484040899 cites W1693362192 @default.
• W1484040899 cites W1776917887 @default.
• W1484040899 cites W1808793770 @default.
• W1484040899 cites W1974981229 @default.
• W1484040899 cites W1977307548 @default.
• W1484040899 cites W1988091971 @default.
• W1484040899 cites W2000668167 @default.
• W1484040899 cites W2010132500 @default.
• W1484040899 cites W2017686523 @default.
• W1484040899 cites W2022564995 @default.
• W1484040899 cites W2043419877 @default.
• W1484040899 cites W2045026743 @default.
• W1484040899 cites W2046642028 @default.
• W1484040899 cites W2047116228 @default.
• W1484040899 cites W2048492583 @default.
• W1484040899 cites W2059797601 @default.
• W1484040899 cites W2068306635 @default.
• W1484040899 cites W2081490747 @default.
• W1484040899 cites W2082571535 @default.
• W1484040899 cites W2083897082 @default.
• W1484040899 cites W2092981603 @default.
• W1484040899 cites W2097597586 @default.
• W1484040899 cites W2098539652 @default.
• W1484040899 cites W2100837269 @default.
• W1484040899 cites W2107754720 @default.
• W1484040899 cites W2263512616 @default.
• W1484040899 cites W2412008260 @default.
• W1484040899 cites W4234690388 @default.
• W1484040899 cites W70018333 @default.
• W1484040899 cites W76936406 @default.
• W1484040899 doi "https://doi.org/10.1016/0006-2952(91)90557-l" @default.
• W1484040899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2018550" @default.
• W1484040899 hasPublicationYear "1991" @default.
• W1484040899 type Work @default.
• W1484040899 sameAs 1484040899 @default.
• W1484040899 citedByCount "25" @default.
• W1484040899 countsByYear W14840408992012 @default.
• W1484040899 countsByYear W14840408992014 @default.
• W1484040899 countsByYear W14840408992022 @default.
• W1484040899 countsByYear W14840408992023 @default.
• W1484040899 crossrefType "journal-article" @default.
• W1484040899 hasAuthorship W1484040899A5015036022 @default.
• W1484040899 hasAuthorship W1484040899A5043457314 @default.
• W1484040899 hasAuthorship W1484040899A5054258694 @default.
• W1484040899 hasAuthorship W1484040899A5070312706 @default.
• W1484040899 hasConcept C126322002 @default.
• W1484040899 hasConcept C127078168 @default.
• W1484040899 hasConcept C134018914 @default.
• W1484040899 hasConcept C150903083 @default.
• W1484040899 hasConcept C168240541 @default.
• W1484040899 hasConcept C170493617 @default.
• W1484040899 hasConcept C181199279 @default.
• W1484040899 hasConcept C185592680 @default.
• W1484040899 hasConcept C207001950 @default.
• W1484040899 hasConcept C2780091579 @default.
• W1484040899 hasConcept C28859421 @default.
• W1484040899 hasConcept C38485361 @default.
• W1484040899 hasConcept C55493867 @default.
• W1484040899 hasConcept C62231903 @default.
• W1484040899 hasConcept C71924100 @default.
• W1484040899 hasConcept C86803240 @default.
• W1484040899 hasConceptScore W1484040899C126322002 @default.
• W1484040899 hasConceptScore W1484040899C127078168 @default.
• W1484040899 hasConceptScore W1484040899C134018914 @default.
• W1484040899 hasConceptScore W1484040899C150903083 @default.
• W1484040899 hasConceptScore W1484040899C168240541 @default.
• W1484040899 hasConceptScore W1484040899C170493617 @default.
• W1484040899 hasConceptScore W1484040899C181199279 @default.
• W1484040899 hasConceptScore W1484040899C185592680 @default.
• W1484040899 hasConceptScore W1484040899C207001950 @default.
• W1484040899 hasConceptScore W1484040899C2780091579 @default.
• W1484040899 hasConceptScore W1484040899C28859421 @default.
• W1484040899 hasConceptScore W1484040899C38485361 @default.
• W1484040899 hasConceptScore W1484040899C55493867 @default.
• W1484040899 hasConceptScore W1484040899C62231903 @default.
• W1484040899 hasConceptScore W1484040899C71924100 @default.
• W1484040899 hasConceptScore W1484040899C86803240 @default.
• W1484040899 hasIssue "10" @default.
• W1484040899 hasLocation W14840408991 @default.
• W1484040899 hasLocation W14840408992 @default.
• W1484040899 hasOpenAccess W1484040899 @default.
• W1484040899 hasPrimaryLocation W14840408991 @default.
• W1484040899 hasRelatedWork W1987492845 @default.
• W1484040899 hasRelatedWork W1997567148 @default.
• W1484040899 hasRelatedWork W2022578033 @default.
• W1484040899 hasRelatedWork W2042033030 @default.

• next