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- W1484089804 abstract "Abstract Elevated sympathetic outflow contributes to hypertension in obesity. Orexins importantly regulates autonomic function. Presently we determined the role of orexin in the paraventricular (PVN) nucleus of hypothalamus in controlling sympathetic outflow in obese Zucker rats (OZRs) and lean Zucker rats (LZRs). Orexin A microinjection into PVN significiantly dose-dependently elevated arterial blood pressure (ABP) and renal sympathetic nerve activity (RSNA) manner in anesthetized OZRs than LZRs, which eliminated by SB-334867, orexin receptor 1 receptor (OX1R) antagonist, but not TCS-OX2-29, OX2R antagonist. Furthermore, SB-334867 reduced basal ABP and RSNA in OZRs but not LZRs. Compared with LZRs, OX1R expression in PVN was significantly higher in OZRs, while no difference for OX2R. OX1R immunoreactivity was positive in retrogradely labeled PVN-spinal neurons. Compared with LZRs, the basal firing rate in the PVN-spinal neurons was higher in OZRs, and orexin A excited firing activity in PVN-spinal neuron..." @default.
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- W1484089804 date "2015-04-01" @default.
- W1484089804 modified "2023-09-27" @default.
- W1484089804 title "Upregulation of Orexin Receptor in Paraventricular Nucleus Promotes Sympathetic Outflow Through Non‐selective Cation Channel in Obesity" @default.
- W1484089804 doi "https://doi.org/10.1096/fasebj.29.1_supplement.647.5" @default.
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