FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484166110> ?p ?o ?g. }

• W1484166110 abstract "Summary 1.Physiological Studies on Gastric Acid Secretion after Oral Administration. In only a dozen or so reasonably controlled studies have oral anticholinergics been shown to have a significant effect on gastric acid secretion. Of these, an effect could be shown on basal acid output in maximal doses recommended by the manufacturer to well above the maximal recommended dose (e.g., 10 times the recommended dose). Even at these doses, in only about six studies could an effect be shown on augmented histamine secretion. 2.Salivary secretion. At doses having an effect on gastric acid secretion salivary secretion was also reduced. There is no evidence for any drug of a selective effect on the stomach. 3.Controlled clinical trials. Only a small number of studies have been done. Of these slightly fewer show a beneficial effect (six for) compared to no significant effect (nine against), as regards increased healing rate, decreased symptoms, recurrence, or complication rate. The possible beneficial effects of these drugs do not appear to be sufficiently clear cut in the majority of patients to warrant the side effects from the drugs. 4.Dosage. Anticholinergics must be given in optimal effective doses.55 The dose needed is usually at least that maximally recommended by the manufacturer at 6-hr intervals, even for so-called long-acting drugs. At these doses, the incidence of side effects may be such that many patients will not tolerate these drugs for prolonged periods. In other cases safety factors may be a deterrent. 5.Drug type. For physicochemical reasons, tertiary ammonium compounds are better absorbed across the gastrointestinal tract of man than the synthetic quaternary ammonium compounds. The use of tertiary compounds (besides being much cheaper for the naturally occurring compounds) is therefore to be generally recommended. Absence of side effects with quaternary ammonium drugs may be due to decreased gastrointestinal absorption. 6.Recommendations. If used at all in peptic ulcer disease, anti cholinergics should be reserved for: (1) persistent pain, especially nocturnal pain not responding to routine measure; (2) patients whose ulcer is failing to heal after an adequate trial of routine measures, or (3) patients with a high ulcer recurrence rate interfering with their livelihood on account of symptoms or complications." @default.
• W1484166110 created "2016-06-24" @default.
• W1484166110 creator A5021855029 @default.
• W1484166110 date "1975-01-01" @default.
• W1484166110 modified "2023-09-24" @default.
• W1484166110 title "Anticholinergics: Do They Work in Peptic Ulcer?" @default.
• W1484166110 cites W1412780953 @default.
• W1484166110 cites W1603574195 @default.
• W1484166110 cites W1663190366 @default.
• W1484166110 cites W1704326380 @default.
• W1484166110 cites W1770313481 @default.
• W1484166110 cites W1941872093 @default.
• W1484166110 cites W1967233999 @default.
• W1484166110 cites W1967791881 @default.
• W1484166110 cites W1968254072 @default.
• W1484166110 cites W1971094791 @default.
• W1484166110 cites W1974706511 @default.
• W1484166110 cites W1981196940 @default.
• W1484166110 cites W1987787401 @default.
• W1484166110 cites W1993041738 @default.
• W1484166110 cites W1993355507 @default.
• W1484166110 cites W1994136678 @default.
• W1484166110 cites W1996062889 @default.
• W1484166110 cites W2000969978 @default.
• W1484166110 cites W2002954563 @default.
• W1484166110 cites W2004621904 @default.
• W1484166110 cites W2005398573 @default.
• W1484166110 cites W200960439 @default.
• W1484166110 cites W2012178522 @default.
• W1484166110 cites W2016662242 @default.
• W1484166110 cites W2019127219 @default.
• W1484166110 cites W2019186278 @default.
• W1484166110 cites W2025211059 @default.
• W1484166110 cites W2026826801 @default.
• W1484166110 cites W2027867936 @default.
• W1484166110 cites W2029826672 @default.
• W1484166110 cites W2033774340 @default.
• W1484166110 cites W2036267679 @default.
• W1484166110 cites W2040861028 @default.
• W1484166110 cites W2042793975 @default.
• W1484166110 cites W2047119372 @default.
• W1484166110 cites W2054943146 @default.
• W1484166110 cites W2064041756 @default.
• W1484166110 cites W2066663966 @default.
• W1484166110 cites W2073636004 @default.
• W1484166110 cites W2073683534 @default.
• W1484166110 cites W2074490049 @default.
• W1484166110 cites W2074949244 @default.
• W1484166110 cites W2080416279 @default.
• W1484166110 cites W2093481476 @default.
• W1484166110 cites W2096998583 @default.
• W1484166110 cites W2141839998 @default.
• W1484166110 cites W2150018928 @default.
• W1484166110 cites W2156267645 @default.
• W1484166110 cites W2158605053 @default.
• W1484166110 cites W2158758552 @default.
• W1484166110 cites W2224578923 @default.
• W1484166110 cites W2264648641 @default.
• W1484166110 cites W2312202041 @default.
• W1484166110 cites W2339987458 @default.
• W1484166110 cites W2341314610 @default.
• W1484166110 cites W2395500986 @default.
• W1484166110 cites W2397975435 @default.
• W1484166110 cites W2404535605 @default.
• W1484166110 cites W2405727526 @default.
• W1484166110 cites W2411385214 @default.
• W1484166110 cites W2417089051 @default.
• W1484166110 cites W2417367817 @default.
• W1484166110 cites W2417389572 @default.
• W1484166110 cites W2417881456 @default.
• W1484166110 cites W2923917193 @default.
• W1484166110 cites W2941349702 @default.
• W1484166110 cites W4302032678 @default.
• W1484166110 cites W2024685650 @default.
• W1484166110 doi "https://doi.org/10.1016/s0016-5085(75)80062-x" @default.
• W1484166110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1090477" @default.
• W1484166110 hasPublicationYear "1975" @default.
• W1484166110 type Work @default.
• W1484166110 sameAs 1484166110 @default.
• W1484166110 citedByCount "44" @default.
• W1484166110 crossrefType "journal-article" @default.
• W1484166110 hasAuthorship W1484166110A5021855029 @default.
• W1484166110 hasConcept C1122143 @default.
• W1484166110 hasConcept C126322002 @default.
• W1484166110 hasConcept C2777504413 @default.
• W1484166110 hasConcept C2778024521 @default.
• W1484166110 hasConcept C2779306644 @default.
• W1484166110 hasConcept C2779390736 @default.
• W1484166110 hasConcept C2779422922 @default.
• W1484166110 hasConcept C2780035454 @default.
• W1484166110 hasConcept C2780656511 @default.
• W1484166110 hasConcept C2994200661 @default.
• W1484166110 hasConcept C49039625 @default.
• W1484166110 hasConcept C71924100 @default.
• W1484166110 hasConcept C90924648 @default.
• W1484166110 hasConcept C98274493 @default.
• W1484166110 hasConceptScore W1484166110C1122143 @default.
• W1484166110 hasConceptScore W1484166110C126322002 @default.
• W1484166110 hasConceptScore W1484166110C2777504413 @default.
• W1484166110 hasConceptScore W1484166110C2778024521 @default.

• next