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- W1484252807 abstract "Nelson (4) injected 32 guinea pigs with various estrogens for periods ranging from 2 to io months, and in 6 of these animals succeeded in producing in the cornua or fundus of the uterus one or more growths which appeared to be definitely fibromyomatous. Lipschiitz (2) and collaborators, in an extended series of experiments, produced similar tumors not only on the uterus but on many of the abdominal organs, including the stomach, spleen, and omentum. He noted that ovariectomized guinea pigs almost invariably developed growths after the administration twice weekly for 2 to 3 months of 80 mgm. of estradiol benzoate. The tumors that resulted were not observed to undergo malignant change. A second group of 3 male guinea pigs received estradiol benzoate pellets in the same manner , without prel iminary operative procedure. Two pellets weighed 25 mgm., the third 5 ~ mgm. One of the animals with a 25 mgm. pellet was allowed to live 9 ~ days, the other two were kept for i48 days and then killed." @default.
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- W1484252807 date "1941-05-01" @default.
- W1484252807 modified "2023-09-28" @default.
- W1484252807 title "Tumors Produced by Estradiol Benzoate in the Guinea Pig" @default.
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