Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484277267> ?p ?o ?g. }
- W1484277267 endingPage "2171" @default.
- W1484277267 startingPage "2162" @default.
- W1484277267 abstract "Modifying the chromatin structure and interacting with non-histone proteins, histone deacetylases (HDAC) are involved in vital cellular processes at different levels. We here specifically investigated the direct effects of HDAC5 in macrophage activation in response to bacterial or cytokine stimuli. Using murine and human macrophage cell lines, we studied the expression profile and the immunological function of HDAC5 at transcription and protein level in over-expression as well as RNA interference experiments. Toll-like receptor-mediated stimulation of murine RAW264.7 cells significantly reduced HDAC5 mRNA within 7 hrs but presented baseline levels after 24 hrs, a mechanism that was also found for Interferon-γ treatment. If treated with lipopolysaccharide, RAW264.7 cells transfected for over-expression only of full-length but not of mutant HDAC5, significantly elevated secretion of tumour necrosis factor α and of the monocyte chemotactic protein-1. These effects were accompanied by increased nuclear factor-κB activity. Accordingly, knock down of HDAC5-mRNA expression using specific siRNA significantly reduced the production of these cytokines in RAW264.7 or human U937 cells. Taken together, our results suggest a strong regulatory function of HDAC5 in the pro-inflammatory response of macrophages." @default.
- W1484277267 created "2016-06-24" @default.
- W1484277267 creator A5000657084 @default.
- W1484277267 creator A5008770927 @default.
- W1484277267 creator A5018044368 @default.
- W1484277267 creator A5031092899 @default.
- W1484277267 creator A5060525597 @default.
- W1484277267 creator A5061216679 @default.
- W1484277267 creator A5084764808 @default.
- W1484277267 date "2015-06-08" @default.
- W1484277267 modified "2023-10-01" @default.
- W1484277267 title "Histone deacetylase 5 regulates the inflammatory response of macrophages" @default.
- W1484277267 cites W1506982292 @default.
- W1484277267 cites W1566452145 @default.
- W1484277267 cites W1636901091 @default.
- W1484277267 cites W1923917571 @default.
- W1484277267 cites W1972756318 @default.
- W1484277267 cites W1975516847 @default.
- W1484277267 cites W1976933461 @default.
- W1484277267 cites W1982387659 @default.
- W1484277267 cites W1988920329 @default.
- W1484277267 cites W1997274559 @default.
- W1484277267 cites W2006588622 @default.
- W1484277267 cites W2006734059 @default.
- W1484277267 cites W2029907758 @default.
- W1484277267 cites W2038554263 @default.
- W1484277267 cites W2040222339 @default.
- W1484277267 cites W2049428247 @default.
- W1484277267 cites W2051257692 @default.
- W1484277267 cites W2056912730 @default.
- W1484277267 cites W2066758152 @default.
- W1484277267 cites W2068906355 @default.
- W1484277267 cites W2073978750 @default.
- W1484277267 cites W2085187903 @default.
- W1484277267 cites W2087966689 @default.
- W1484277267 cites W2090348764 @default.
- W1484277267 cites W2094996679 @default.
- W1484277267 cites W2097463480 @default.
- W1484277267 cites W2101924021 @default.
- W1484277267 cites W2108017291 @default.
- W1484277267 cites W2109305602 @default.
- W1484277267 cites W2112042684 @default.
- W1484277267 cites W2116459790 @default.
- W1484277267 cites W2133446638 @default.
- W1484277267 cites W2134422149 @default.
- W1484277267 cites W2138049320 @default.
- W1484277267 cites W2141265087 @default.
- W1484277267 cites W2154572495 @default.
- W1484277267 cites W2155947420 @default.
- W1484277267 cites W2158622145 @default.
- W1484277267 cites W2162432494 @default.
- W1484277267 cites W2166197839 @default.
- W1484277267 cites W2167415368 @default.
- W1484277267 cites W2168680690 @default.
- W1484277267 cites W2307241 @default.
- W1484277267 cites W31775548 @default.
- W1484277267 doi "https://doi.org/10.1111/jcmm.12595" @default.
- W1484277267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4568921" @default.
- W1484277267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26059794" @default.
- W1484277267 hasPublicationYear "2015" @default.
- W1484277267 type Work @default.
- W1484277267 sameAs 1484277267 @default.
- W1484277267 citedByCount "43" @default.
- W1484277267 countsByYear W14842772672016 @default.
- W1484277267 countsByYear W14842772672017 @default.
- W1484277267 countsByYear W14842772672018 @default.
- W1484277267 countsByYear W14842772672019 @default.
- W1484277267 countsByYear W14842772672020 @default.
- W1484277267 countsByYear W14842772672021 @default.
- W1484277267 countsByYear W14842772672022 @default.
- W1484277267 countsByYear W14842772672023 @default.
- W1484277267 crossrefType "journal-article" @default.
- W1484277267 hasAuthorship W1484277267A5000657084 @default.
- W1484277267 hasAuthorship W1484277267A5008770927 @default.
- W1484277267 hasAuthorship W1484277267A5018044368 @default.
- W1484277267 hasAuthorship W1484277267A5031092899 @default.
- W1484277267 hasAuthorship W1484277267A5060525597 @default.
- W1484277267 hasAuthorship W1484277267A5061216679 @default.
- W1484277267 hasAuthorship W1484277267A5084764808 @default.
- W1484277267 hasBestOaLocation W14842772672 @default.
- W1484277267 hasConcept C101762097 @default.
- W1484277267 hasConcept C104317684 @default.
- W1484277267 hasConcept C108634530 @default.
- W1484277267 hasConcept C134320426 @default.
- W1484277267 hasConcept C150194340 @default.
- W1484277267 hasConcept C17991360 @default.
- W1484277267 hasConcept C203014093 @default.
- W1484277267 hasConcept C27253355 @default.
- W1484277267 hasConcept C2778305200 @default.
- W1484277267 hasConcept C2778690821 @default.
- W1484277267 hasConcept C54355233 @default.
- W1484277267 hasConcept C55493867 @default.
- W1484277267 hasConcept C64927066 @default.
- W1484277267 hasConcept C81885089 @default.
- W1484277267 hasConcept C86339819 @default.
- W1484277267 hasConcept C86803240 @default.
- W1484277267 hasConcept C95444343 @default.
- W1484277267 hasConceptScore W1484277267C101762097 @default.