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- W1484296768 abstract "Small GTPases of the Arf family control many aspects of membrane traffic and organelle structure. They are activated by guanine nucleotide exchange factors (ArfGEFs), which are modular proteins composed of a catalytic Sec7 domain that stimulates GDP/GTP exchange, and other domains that carry out regulatory and membrane targeting functions [1]. We will present our recent results on BRAG and EFA6 GEFs, which activate Arf GTPases in endocytic events. Biochemical reconstitution of Arf activation on membranes combined with structural analysis revealed that membranes dramatically affect ArfGEF efficiency [2]. These studies also uncovered an unexpected diversity of regulatory regimes, which suggest that ArfGEFs establish coupled positive-negative feedback circuits to shape the level and timing of Arf activation in cells. [1] Cherfils J. and Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 2013. [2] Aizel K. et al., Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2. PLoS Biology 2013. Grant Funding Source: Supported by grants from CNRS, the Association pour la Recherche Contre le Cancer (ARC), from the Agence Nationale de la Recherche (ANR) and from the Cancéropôle Ile-de-France" @default.
- W1484296768 created "2016-06-24" @default.
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- W1484296768 date "2014-04-01" @default.
- W1484296768 modified "2023-09-25" @default.
- W1484296768 title "Biochemical and structural mechanisms of regulation of Arf GTPases by endocytic GEFs (LB259)" @default.
- W1484296768 doi "https://doi.org/10.1096/fasebj.28.1_supplement.lb259" @default.
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