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- W1484390057 endingPage "248" @default.
- W1484390057 startingPage "190" @default.
- W1484390057 abstract "The NMR characterization of the structure function relationship in metalloproteins using high frequency shifted His imidazole ring NH proton signals as spectroscopic probes are reviewed, with examples of the studies of myoglobin, cytochrome c, and superoxide dismutase. His residues are often found as active site residues in a variety of enzymes and metalloproteins and as proton-donor or -acceptor residues in forming internal hydrogen bonds, which contribute to stabilization of protein folding. Since a His imidazole ring NH hydrogen that participates in an internal hydrogen bond within a protein matrix is magnetically deshielded and exhibits a moderate hydrogen exchange rate, its NMR signal is resolved outside the protein envelope, 0–10 ppm. These signals are highly sensitive to electronic structure and microenvironments of His residues and unequivocally describe the tautomerism and the protonation behaviour of the side-chains. NMR parameters of hydrogen-bonded His imidazole ring NH proton signals reflect the strength of the hydrogen bond and the local tertiary structure of the protein and therefore provide unique structural information that cannot be obtained by other techniques." @default.
- W1484390057 created "2016-06-24" @default.
- W1484390057 creator A5067280388 @default.
- W1484390057 date "2002-01-01" @default.
- W1484390057 modified "2023-09-25" @default.
- W1484390057 title "NMR study of internal hydrogen bonds in metalloproteins" @default.
- W1484390057 cites W1491027295 @default.
- W1484390057 cites W1492609838 @default.
- W1484390057 cites W1499408335 @default.
- W1484390057 cites W1507461405 @default.
- W1484390057 cites W1512775211 @default.
- W1484390057 cites W1513701026 @default.
- W1484390057 cites W1514304638 @default.
- W1484390057 cites W1522117607 @default.
- W1484390057 cites W1529025818 @default.
- W1484390057 cites W1531583716 @default.
- W1484390057 cites W1532023928 @default.
- W1484390057 cites W1548646063 @default.
- W1484390057 cites W1551397276 @default.
- W1484390057 cites W1559459407 @default.
- W1484390057 cites W1564273292 @default.
- W1484390057 cites W1571201200 @default.
- W1484390057 cites W1581340549 @default.
- W1484390057 cites W1643426610 @default.
- W1484390057 cites W1697966803 @default.
- W1484390057 cites W1879404298 @default.
- W1484390057 cites W1964389157 @default.
- W1484390057 cites W1964527759 @default.
- W1484390057 cites W1965368050 @default.
- W1484390057 cites W1965597244 @default.
- W1484390057 cites W1966964730 @default.
- W1484390057 cites W1971213643 @default.
- W1484390057 cites W1971468738 @default.
- W1484390057 cites W1973703218 @default.
- W1484390057 cites W1974636083 @default.
- W1484390057 cites W1974828485 @default.
- W1484390057 cites W1975495422 @default.
- W1484390057 cites W1977222497 @default.
- W1484390057 cites W1977309974 @default.
- W1484390057 cites W1978869002 @default.
- W1484390057 cites W1979485645 @default.
- W1484390057 cites W1980891056 @default.
- W1484390057 cites W1981575136 @default.
- W1484390057 cites W1981622776 @default.
- W1484390057 cites W1982063067 @default.
- W1484390057 cites W1983160087 @default.
- W1484390057 cites W1985493699 @default.
- W1484390057 cites W1987160917 @default.
- W1484390057 cites W1987331768 @default.
- W1484390057 cites W1987627782 @default.
- W1484390057 cites W198766237 @default.
- W1484390057 cites W1988915042 @default.
- W1484390057 cites W1989280688 @default.
- W1484390057 cites W1989338402 @default.
- W1484390057 cites W1992257521 @default.
- W1484390057 cites W1993533164 @default.
- W1484390057 cites W1994796405 @default.
- W1484390057 cites W1995139257 @default.
- W1484390057 cites W1995948694 @default.
- W1484390057 cites W1996322649 @default.
- W1484390057 cites W1996939437 @default.
- W1484390057 cites W1997830777 @default.
- W1484390057 cites W1997897669 @default.
- W1484390057 cites W1998022394 @default.
- W1484390057 cites W1999300802 @default.
- W1484390057 cites W1999616324 @default.
- W1484390057 cites W2000569151 @default.
- W1484390057 cites W2005068472 @default.
- W1484390057 cites W2005201158 @default.
- W1484390057 cites W2005423400 @default.
- W1484390057 cites W2005966558 @default.
- W1484390057 cites W2006058557 @default.
- W1484390057 cites W2006274447 @default.
- W1484390057 cites W2006699053 @default.
- W1484390057 cites W2007365285 @default.
- W1484390057 cites W2007614369 @default.
- W1484390057 cites W2010253426 @default.
- W1484390057 cites W2012130165 @default.
- W1484390057 cites W2012959681 @default.
- W1484390057 cites W2016074177 @default.
- W1484390057 cites W2016088806 @default.
- W1484390057 cites W2018871062 @default.
- W1484390057 cites W2024072803 @default.
- W1484390057 cites W2024495148 @default.
- W1484390057 cites W2025153717 @default.
- W1484390057 cites W2025468090 @default.
- W1484390057 cites W2030667985 @default.
- W1484390057 cites W2032875280 @default.
- W1484390057 cites W2033233566 @default.
- W1484390057 cites W2033985605 @default.
- W1484390057 cites W2035072160 @default.
- W1484390057 cites W2035194883 @default.
- W1484390057 cites W2038137702 @default.
- W1484390057 cites W2041288601 @default.
- W1484390057 cites W2042889324 @default.
- W1484390057 cites W2043614133 @default.
- W1484390057 cites W2043701998 @default.
- W1484390057 cites W2046152827 @default.