FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484474567> ?p ?o ?g. }

• W1484474567 abstract "Background: Duchenne muscular dystrophy (DMD) is a genetic disorder in males resulting in muscle weakness leading to loss of ambulation and progression to death by pulmonary and cardiac dysfunction. It has been documented both steroids deflazacort and prednisone delay muscle degeneration but not many studies outline the differences between the two including side effect profiles. Deflazacort is not yet available in the US. This systematic review compiles recent data to compare deflazacort to prednisone in the treatment of DMD boys. Method: A full search of medical literature using multiple databases, MEDLINE, CINAHL, Evidence Based Reviews Multifile and Web of Science, and reference lists was conducted with the key words muscular dystrophy, deflazacort and prednisone. Articles that consisted of the outcomes of muscle function, cardiac and pulmonary changes, side effect incidence and type, and gene expression in whole blood were included. The literature was assessed using the GRADE system to rate its quality and importance. Results: Four articles were selected for review. There were no significant differences between the two steroids in treating muscle functionality, prevention of cardiomyopathy or difference in pulmonary function. In Bonifati et al and Balaban et al, weight gain in prednisone-treated patients was greater than with deflazacort. With regards to gene expression, Lit et al discovered gene probes in the prednisone-treated patients which promote weight gain. On the other hand, deflazacort probes are suspected to prevent obesity. Conclusion: It is clear both steroids are efficacious in treating DMD but side effects will determine patient and providers’ choice of prescription. Further research with randomized control trails over extended time periods is needed to establish the true difference between side effects of deflazacort and prednisone. Research in gene expression holds promise for future utility in the selection of steroid therapy. Degree Type Capstone Project Rights Terms of use for work posted in CommonKnowledge. This capstone project is available at CommonKnowledge: http://commons.pacificu.edu/pa/272 Copyright and terms of use If you have downloaded this document directly from the web or from CommonKnowledge, see the “Rights” section on the previous page for the terms of use. If you have received this document through an interlibrary loan/document delivery service, the following terms of use apply: Copyright in this work is held by the author(s). You may download or print any portion of this document for personal use only, or for any use that is allowed by fair use (Title 17, §107 U.S.C.). Except for personal or fair use, you or your borrowing library may not reproduce, remix, republish, post, transmit, or distribute this document, or any portion thereof, without the permission of the copyright owner. [Note: If this document is licensed under a Creative Commons license (see “Rights” on the previous page) which allows broader usage rights, your use is governed by the terms of that license.] Inquiries regarding further use of these materials should be addressed to: CommonKnowledge Rights, Pacific University Library, 2043 College Way, Forest Grove, OR 97116, (503) 352-7209. Email inquiries may be directed to:. copyright@pacificu.edu This capstone project is available at CommonKnowledge: http://commons.pacificu.edu/pa/272" @default.
• W1484474567 created "2016-06-24" @default.
• W1484474567 creator A5013449174 @default.
• W1484474567 date "2012-01-01" @default.
• W1484474567 modified "2023-09-27" @default.
• W1484474567 title "Deflazacort Versus Prednisone: A Systematic Comparison of two Steroids in the Treatment of Duchenne Muscular Dystrophy" @default.
• W1484474567 cites W1490803713 @default.
• W1484474567 cites W1888941810 @default.
• W1484474567 cites W1967569266 @default.
• W1484474567 cites W1972137179 @default.
• W1484474567 cites W1980035600 @default.
• W1484474567 cites W1986195421 @default.
• W1484474567 cites W1998483343 @default.
• W1484474567 cites W2018358939 @default.
• W1484474567 cites W2018396053 @default.
• W1484474567 cites W2018559734 @default.
• W1484474567 cites W2027622637 @default.
• W1484474567 cites W2031789342 @default.
• W1484474567 cites W2034872844 @default.
• W1484474567 cites W2042394092 @default.
• W1484474567 cites W2042941794 @default.
• W1484474567 cites W2048347092 @default.
• W1484474567 cites W2051741101 @default.
• W1484474567 cites W2067459416 @default.
• W1484474567 cites W2072075432 @default.
• W1484474567 cites W2079886350 @default.
• W1484474567 cites W2080338828 @default.
• W1484474567 cites W2087760263 @default.
• W1484474567 cites W2089449761 @default.
• W1484474567 cites W2096328571 @default.
• W1484474567 cites W2112090184 @default.
• W1484474567 cites W2115297798 @default.
• W1484474567 cites W2115459204 @default.
• W1484474567 cites W2125564749 @default.
• W1484474567 cites W2128448322 @default.
• W1484474567 cites W2141759547 @default.
• W1484474567 cites W2157593661 @default.
• W1484474567 cites W2239673512 @default.
• W1484474567 cites W2243948804 @default.
• W1484474567 cites W2409540771 @default.
• W1484474567 hasPublicationYear "2012" @default.
• W1484474567 type Work @default.
• W1484474567 sameAs 1484474567 @default.
• W1484474567 citedByCount "0" @default.
• W1484474567 crossrefType "journal-article" @default.
• W1484474567 hasAuthorship W1484474567A5013449174 @default.
• W1484474567 hasConcept C126322002 @default.
• W1484474567 hasConcept C1862650 @default.
• W1484474567 hasConcept C187212893 @default.
• W1484474567 hasConcept C2776376305 @default.
• W1484474567 hasConcept C2778720950 @default.
• W1484474567 hasConcept C2778943923 @default.
• W1484474567 hasConcept C2779030066 @default.
• W1484474567 hasConcept C71924100 @default.
• W1484474567 hasConceptScore W1484474567C126322002 @default.
• W1484474567 hasConceptScore W1484474567C1862650 @default.
• W1484474567 hasConceptScore W1484474567C187212893 @default.
• W1484474567 hasConceptScore W1484474567C2776376305 @default.
• W1484474567 hasConceptScore W1484474567C2778720950 @default.
• W1484474567 hasConceptScore W1484474567C2778943923 @default.
• W1484474567 hasConceptScore W1484474567C2779030066 @default.
• W1484474567 hasConceptScore W1484474567C71924100 @default.
• W1484474567 hasLocation W14844745671 @default.
• W1484474567 hasOpenAccess W1484474567 @default.
• W1484474567 hasPrimaryLocation W14844745671 @default.
• W1484474567 hasRelatedWork W1964178552 @default.
• W1484474567 hasRelatedWork W1966641309 @default.
• W1484474567 hasRelatedWork W2001627264 @default.
• W1484474567 hasRelatedWork W2054326218 @default.
• W1484474567 hasRelatedWork W2080393469 @default.
• W1484474567 hasRelatedWork W2326877121 @default.
• W1484474567 hasRelatedWork W2518586701 @default.
• W1484474567 hasRelatedWork W2521335871 @default.
• W1484474567 hasRelatedWork W2586480525 @default.
• W1484474567 hasRelatedWork W2765844665 @default.
• W1484474567 hasRelatedWork W2976316923 @default.
• W1484474567 hasRelatedWork W3004592820 @default.
• W1484474567 isParatext "false" @default.
• W1484474567 isRetracted "false" @default.
• W1484474567 magId "1484474567" @default.
• W1484474567 workType "article" @default.