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- W1484560428 abstract "This chapter presents an overview of the derivatization reagents that have been applied to liquid chromatography/electrospray ionization-mass spectrometry LC-ESI-MS(/MS), focusing on the application to low molecular weight compounds. The use of derivatization reagents enhances the chargeability and hydrophobicity of the analyte of interest to improve the ionization efficiency. Furthermore, the use of some reagents transforms the analytes to the structures that are suitable for tandem mass spectrometry (MS/MS) detection. In these cases, the resulting derivatives can be easily fragmented by collision-induced dissociation (CID), which consequently generates abundant particular product ions for MS detection. The prominent derivatization regents for LC-ESI-MS/MS are indispensable for the sensitive and selective LC-MS bioanalysis of various kinds of compounds in drug discovery and development." @default.
- W1484560428 created "2016-06-24" @default.
- W1484560428 creator A5032883646 @default.
- W1484560428 date "2013-08-30" @default.
- W1484560428 modified "2023-10-16" @default.
- W1484560428 title "Derivatization in LC-MS Bioanalysis" @default.
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- W1484560428 doi "https://doi.org/10.1002/9781118671276.ch19" @default.
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