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- W148458032 abstract "ABSTRACT The herpes simplex virus mutant HSV-1 (HFEM) tsB7 fails to express any detectable viral polypeptides and fails to inhibit host cell protein synthesis in infected cells maintained at the non-permissive temperature. The mutant can complement the growth of other viruses and therefore can enter doubly infected cells. The mutation maps in the middle of the L component in or near genes coding for virion structural proteins and near a previously mapped function regulating inhibition of host cell protein synthesis. Abundant transcripts and mRNA from this region accumulate only after DNA synthesis and thus the gene appears to code for a late protein. All of our data are consistent with the lesion being a defect in a virion structural protein required for expression of all early viral gene products and possibly for inhibition of host cell protein synthesis. This mutation defines a new early stage of infection prior to expression of any viral gene products at which the replication of herpes simplex virus can be regulated." @default.
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- W148458032 date "1980-01-01" @default.
- W148458032 modified "2023-09-25" @default.
- W148458032 title "A GENE FUNCTION OF HERPES SIMPLEX VIRUS REQUIRED FOR EXPRESSION OF ALL EARLY VIRAL GENES" @default.
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- W148458032 doi "https://doi.org/10.1016/b978-0-12-255850-4.50037-8" @default.
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