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• W1484582783 abstract "Eukaryotic 20S proteasomes harbor a remarkably complex architecture and unique proteolytic properties. Its catalytic mechanism places this enzyme in a new kind of protease family. The recently solved crystal structure of the yeast 20S complex, along with elucidation of the maturation pathway of human proteasomes, has allowed insight into structure/function relationships. Although not all of the unusual enzymatic properties such as broad substrate specificity, predominant generation of peptides with a specific size, or susceptibility to activating complexes can be explained in detail, knowledge of the structure provides important hints for an explanation of underlying mechanisms. Except for ribosome biogenesis, the complexity of eukaryotic proteasome maturation is without precedence. It is a slow process that involves a series of precisely ordered events. Proteasome structure formation is characterized by an initial cooperative formation of an α ring matrix, providing docking sites for a defined subset of β subunits. Subsequent structural rearrangement allows the residual subunits to bind, followed by dimerization of two half-proteasomes. The prosequences of β subunits exert specific functions during this process and are removed by cis-and trans-autocatalysis, most likely in the completely assembled proteasome cylinder.—Schmidt, M., Kloetzel, P.-M. Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme. FASEB J. 11, 1235–1243 (1997)" @default.
• W1484582783 created "2016-06-24" @default.
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• W1484582783 date "1997-12-01" @default.
• W1484582783 modified "2023-10-03" @default.
• W1484582783 title "Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme" @default.
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• W1484582783 doi "https://doi.org/10.1096/fasebj.11.14.9409542" @default.
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