Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484600289> ?p ?o ?g. }
- W1484600289 endingPage "3299" @default.
- W1484600289 startingPage "3287" @default.
- W1484600289 abstract "Intermittent hypoxia (IH) is thought to be responsible for many of the long-term cardiovascular consequences associated with obstructive sleep apnoea (OSA). Experimental human models of IH can aid in investigating the pathophysiology of these cardiovascular complications. The purpose of this study was to determine the effects of IH on the cardiovascular and cerebrovascular response to acute hypoxia and hypercapnia in an experimental human model that simulates the hypoxaemia experienced by OSA patients. We exposed 10 healthy, male subjects to IH for 4 consecutive days. The IH profile involved 2 min of hypoxia (nadir = 45.0 mmHg) alternating with 2 min of normoxia (peak = 88.0 mmHg) for 6 h. The cerebral blood flow response and the pressor responses to hypoxia and hypercapnia were assessed after 2 days of sham exposure, after each day of IH, and 4 days following the discontinuation of IH. Nitric oxide derivatives were measured at baseline and following the last exposure to IH. After 4 days of IH, mean arterial pressure increased by 4 mmHg (P < 0.01), nitric oxide derivatives were reduced by 55% (P < 0.05), the pressor response to acute hypoxia increased (P < 0.01), and the cerebral vascular resistance response to hypoxia increased (P < 0.01). IH alters blood pressure and cerebrovascular regulation, which is likely to contribute to the pathogenesis of cardiovascular and cerebrovascular disease in patients with OSA." @default.
- W1484600289 created "2016-06-24" @default.
- W1484600289 creator A5003377582 @default.
- W1484600289 creator A5011785147 @default.
- W1484600289 creator A5028082580 @default.
- W1484600289 creator A5037785427 @default.
- W1484600289 creator A5080815644 @default.
- W1484600289 creator A5086806040 @default.
- W1484600289 creator A5088349274 @default.
- W1484600289 date "2009-06-30" @default.
- W1484600289 modified "2023-09-30" @default.
- W1484600289 title "Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans" @default.
- W1484600289 cites W1580180188 @default.
- W1484600289 cites W1630922010 @default.
- W1484600289 cites W1727781969 @default.
- W1484600289 cites W1789910835 @default.
- W1484600289 cites W1964699959 @default.
- W1484600289 cites W1965644737 @default.
- W1484600289 cites W1970386234 @default.
- W1484600289 cites W1988114644 @default.
- W1484600289 cites W1990802251 @default.
- W1484600289 cites W1990988256 @default.
- W1484600289 cites W2020496288 @default.
- W1484600289 cites W2035526146 @default.
- W1484600289 cites W2035614693 @default.
- W1484600289 cites W2036476503 @default.
- W1484600289 cites W2040378078 @default.
- W1484600289 cites W2049165834 @default.
- W1484600289 cites W2052244174 @default.
- W1484600289 cites W2053499282 @default.
- W1484600289 cites W2054025179 @default.
- W1484600289 cites W2054501537 @default.
- W1484600289 cites W2055795971 @default.
- W1484600289 cites W2063874268 @default.
- W1484600289 cites W2071529950 @default.
- W1484600289 cites W2077837756 @default.
- W1484600289 cites W2091937552 @default.
- W1484600289 cites W2099381868 @default.
- W1484600289 cites W2103939721 @default.
- W1484600289 cites W2105644947 @default.
- W1484600289 cites W2109120890 @default.
- W1484600289 cites W2112499003 @default.
- W1484600289 cites W2117075490 @default.
- W1484600289 cites W2122956038 @default.
- W1484600289 cites W2127030366 @default.
- W1484600289 cites W2130853939 @default.
- W1484600289 cites W2131418380 @default.
- W1484600289 cites W2136587191 @default.
- W1484600289 cites W2137125252 @default.
- W1484600289 cites W2137715034 @default.
- W1484600289 cites W2138659796 @default.
- W1484600289 cites W2139480984 @default.
- W1484600289 cites W2139704316 @default.
- W1484600289 cites W2140058549 @default.
- W1484600289 cites W2140446943 @default.
- W1484600289 cites W2140775428 @default.
- W1484600289 cites W2147408183 @default.
- W1484600289 cites W2154892885 @default.
- W1484600289 cites W2166509587 @default.
- W1484600289 cites W2167925671 @default.
- W1484600289 cites W2177265491 @default.
- W1484600289 cites W2178591638 @default.
- W1484600289 cites W2235933797 @default.
- W1484600289 cites W2264784497 @default.
- W1484600289 cites W2335449614 @default.
- W1484600289 cites W2410090778 @default.
- W1484600289 cites W2471195096 @default.
- W1484600289 cites W2785563066 @default.
- W1484600289 doi "https://doi.org/10.1113/jphysiol.2009.171553" @default.
- W1484600289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2727037" @default.
- W1484600289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19417094" @default.
- W1484600289 hasPublicationYear "2009" @default.
- W1484600289 type Work @default.
- W1484600289 sameAs 1484600289 @default.
- W1484600289 citedByCount "87" @default.
- W1484600289 countsByYear W14846002892012 @default.
- W1484600289 countsByYear W14846002892013 @default.
- W1484600289 countsByYear W14846002892014 @default.
- W1484600289 countsByYear W14846002892015 @default.
- W1484600289 countsByYear W14846002892016 @default.
- W1484600289 countsByYear W14846002892017 @default.
- W1484600289 countsByYear W14846002892018 @default.
- W1484600289 countsByYear W14846002892019 @default.
- W1484600289 countsByYear W14846002892020 @default.
- W1484600289 countsByYear W14846002892021 @default.
- W1484600289 countsByYear W14846002892022 @default.
- W1484600289 countsByYear W14846002892023 @default.
- W1484600289 crossrefType "journal-article" @default.
- W1484600289 hasAuthorship W1484600289A5003377582 @default.
- W1484600289 hasAuthorship W1484600289A5011785147 @default.
- W1484600289 hasAuthorship W1484600289A5028082580 @default.
- W1484600289 hasAuthorship W1484600289A5037785427 @default.
- W1484600289 hasAuthorship W1484600289A5080815644 @default.
- W1484600289 hasAuthorship W1484600289A5086806040 @default.
- W1484600289 hasAuthorship W1484600289A5088349274 @default.
- W1484600289 hasBestOaLocation W14846002893 @default.
- W1484600289 hasConcept C126322002 @default.
- W1484600289 hasConcept C157767197 @default.