Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484685189> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1484685189 endingPage "5083" @default.
- W1484685189 startingPage "5077" @default.
- W1484685189 abstract "Abstract The mechanisms of immunosuppression induced by colon cancer in rats were investigated at the systemic and tumor levels. During tumor growth (after i.p. injection of rat colon adenocarcinoma cells in syngeneic BD IX rats), Con A-induced proliferation of splenic mononuclear cells decreased and nitric oxide (NO) production by splenic macrophages increased concomitantly. Incubating splenic mononuclear cells with an inhibitor of NO synthase, NG-monomethyl-L-arginine, restored lymphocyte proliferation. A low level of inducible NO synthase mRNA was detectable in tumors by Northern blotting, with a weak increase during tumor growth. The NO concentration measured in the tumor nodules increased weakly parallel to the tumor growth. Five and six weeks after tumor cell injection, tumor-infiltrating lymphocytes from disaggregated tumors did not proliferate in the presence of Con A. Addition of NG-monomethyl-L-arginine inhibited the production of NO in tumor dissociations and enhanced tumor-infiltrating lymphocyte proliferation. Glyceryl trinitrate (a NO-releasing compound) totally inhibited the lymphocyte proliferation in vitro while it slightly reduced the tumor cell proliferation. T lymphocytes were therefore more sensitive to NO than were tumor cells. Culture medium from tumor cells induced NO production by splenic macrophages, although the factor involved has not yet been identified. Furthermore, tumor cells could also play a part in NO production by tumors because the tumor cells were induced to produce NO by IFN-gamma plus IL-1. These results strongly suggest the participation of NO in the tumor-induced immunosuppression in rats." @default.
- W1484685189 created "2016-06-24" @default.
- W1484685189 creator A5054903469 @default.
- W1484685189 creator A5062847164 @default.
- W1484685189 creator A5082298580 @default.
- W1484685189 creator A5085655768 @default.
- W1484685189 creator A5085869386 @default.
- W1484685189 creator A5091168690 @default.
- W1484685189 date "1994-05-15" @default.
- W1484685189 modified "2023-10-18" @default.
- W1484685189 title "Nitric oxide involvement in tumor-induced immunosuppression." @default.
- W1484685189 doi "https://doi.org/10.4049/jimmunol.152.10.5077" @default.
- W1484685189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7513729" @default.
- W1484685189 hasPublicationYear "1994" @default.
- W1484685189 type Work @default.
- W1484685189 sameAs 1484685189 @default.
- W1484685189 citedByCount "130" @default.
- W1484685189 countsByYear W14846851892012 @default.
- W1484685189 countsByYear W14846851892013 @default.
- W1484685189 countsByYear W14846851892015 @default.
- W1484685189 countsByYear W14846851892017 @default.
- W1484685189 countsByYear W14846851892019 @default.
- W1484685189 countsByYear W14846851892021 @default.
- W1484685189 countsByYear W14846851892022 @default.
- W1484685189 countsByYear W14846851892023 @default.
- W1484685189 crossrefType "journal-article" @default.
- W1484685189 hasAuthorship W1484685189A5054903469 @default.
- W1484685189 hasAuthorship W1484685189A5062847164 @default.
- W1484685189 hasAuthorship W1484685189A5082298580 @default.
- W1484685189 hasAuthorship W1484685189A5085655768 @default.
- W1484685189 hasAuthorship W1484685189A5085869386 @default.
- W1484685189 hasAuthorship W1484685189A5091168690 @default.
- W1484685189 hasBestOaLocation W14846851891 @default.
- W1484685189 hasConcept C134018914 @default.
- W1484685189 hasConcept C137061746 @default.
- W1484685189 hasConcept C153911025 @default.
- W1484685189 hasConcept C185592680 @default.
- W1484685189 hasConcept C202751555 @default.
- W1484685189 hasConcept C203014093 @default.
- W1484685189 hasConcept C2777622882 @default.
- W1484685189 hasConcept C2777701055 @default.
- W1484685189 hasConcept C2777761686 @default.
- W1484685189 hasConcept C2778326572 @default.
- W1484685189 hasConcept C2780252810 @default.
- W1484685189 hasConcept C502942594 @default.
- W1484685189 hasConcept C519581460 @default.
- W1484685189 hasConcept C55493867 @default.
- W1484685189 hasConcept C86803240 @default.
- W1484685189 hasConcept C8891405 @default.
- W1484685189 hasConceptScore W1484685189C134018914 @default.
- W1484685189 hasConceptScore W1484685189C137061746 @default.
- W1484685189 hasConceptScore W1484685189C153911025 @default.
- W1484685189 hasConceptScore W1484685189C185592680 @default.
- W1484685189 hasConceptScore W1484685189C202751555 @default.
- W1484685189 hasConceptScore W1484685189C203014093 @default.
- W1484685189 hasConceptScore W1484685189C2777622882 @default.
- W1484685189 hasConceptScore W1484685189C2777701055 @default.
- W1484685189 hasConceptScore W1484685189C2777761686 @default.
- W1484685189 hasConceptScore W1484685189C2778326572 @default.
- W1484685189 hasConceptScore W1484685189C2780252810 @default.
- W1484685189 hasConceptScore W1484685189C502942594 @default.
- W1484685189 hasConceptScore W1484685189C519581460 @default.
- W1484685189 hasConceptScore W1484685189C55493867 @default.
- W1484685189 hasConceptScore W1484685189C86803240 @default.
- W1484685189 hasConceptScore W1484685189C8891405 @default.
- W1484685189 hasIssue "10" @default.
- W1484685189 hasLocation W14846851891 @default.
- W1484685189 hasLocation W14846851892 @default.
- W1484685189 hasOpenAccess W1484685189 @default.
- W1484685189 hasPrimaryLocation W14846851891 @default.
- W1484685189 hasRelatedWork W1971115973 @default.
- W1484685189 hasRelatedWork W2009339464 @default.
- W1484685189 hasRelatedWork W2057619175 @default.
- W1484685189 hasRelatedWork W2072106054 @default.
- W1484685189 hasRelatedWork W2074766836 @default.
- W1484685189 hasRelatedWork W2085967611 @default.
- W1484685189 hasRelatedWork W2147996070 @default.
- W1484685189 hasRelatedWork W2284130322 @default.
- W1484685189 hasRelatedWork W2358232477 @default.
- W1484685189 hasRelatedWork W4313374359 @default.
- W1484685189 hasVolume "152" @default.
- W1484685189 isParatext "false" @default.
- W1484685189 isRetracted "false" @default.
- W1484685189 magId "1484685189" @default.
- W1484685189 workType "article" @default.