Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484817245> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1484817245 endingPage "1238" @default.
- W1484817245 startingPage "1232" @default.
- W1484817245 abstract "Hydroxybenzylpindolol (HYP) is a specific and highly potent beta-adrenergic antagonist. Monoiodination of HYP produces an equally high affinity inhibitor of binding to and activation of the beta receptor-coupled adenylate cyclase in turkey erythrocyte membranes. Monoiodohydroxybenzylpindolol was isolated by high pressure liquid chromatography. Mass spectroscopy showed that the iodine was contained in the phenolic moiety of the molecule. 125I-HYP was purified in tracer amounts by ion exchange chromatography; specific activities were achieved (1500 to 2000 Ci/mmol) approaching theoretical for 1 mol of iodine/mol of HYP. 125I-HYP interacts with a single stereospecific site with affinity of 4 to 5 X 10(10) M-1 by Scatchard analysis. Maximal binding capacity was 0.2 to 0.3 pmol/mg of membrane protein. If recovery of receptor were complete, this would correspond to 400 to 600 receptor sites per cell. Kinetic analyses of the on and off reactions gave a kinetically derived KA in good agreement with that derived from thermodynamic methods both at 20 degrees and 37 degrees. No evidence is found in these experiments for cooperative interaction of ligands with the receptor system. Iodohydroxybenzylpindolol thus represents a high affinity, high specific activity ligand of established chemical structure which should prove useful in studying the interaction of other blockers and agonists with the beta-adrenergic receptor in this and other biological systems." @default.
- W1484817245 created "2016-06-24" @default.
- W1484817245 creator A5020484711 @default.
- W1484817245 creator A5038281830 @default.
- W1484817245 date "1976-03-01" @default.
- W1484817245 modified "2023-09-27" @default.
- W1484817245 title "Beta-Adrenergic receptor interactions. Characterization of iodohydroxybenzylpindolol as a specific ligand." @default.
- W1484817245 cites W113412448 @default.
- W1484817245 cites W1486608945 @default.
- W1484817245 cites W1545031061 @default.
- W1484817245 cites W1657719861 @default.
- W1484817245 cites W1775749144 @default.
- W1484817245 cites W1971836830 @default.
- W1484817245 cites W1983649348 @default.
- W1484817245 cites W1998632508 @default.
- W1484817245 cites W2033785962 @default.
- W1484817245 cites W2046115499 @default.
- W1484817245 cites W2058350823 @default.
- W1484817245 cites W2065468208 @default.
- W1484817245 cites W2068015386 @default.
- W1484817245 cites W2074975964 @default.
- W1484817245 cites W2109389789 @default.
- W1484817245 cites W2162940364 @default.
- W1484817245 cites W2169503005 @default.
- W1484817245 cites W2319687677 @default.
- W1484817245 cites W2335628652 @default.
- W1484817245 cites W2397231873 @default.
- W1484817245 doi "https://doi.org/10.1016/s0021-9258(17)33730-4" @default.
- W1484817245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1254565" @default.
- W1484817245 hasPublicationYear "1976" @default.
- W1484817245 type Work @default.
- W1484817245 sameAs 1484817245 @default.
- W1484817245 citedByCount "107" @default.
- W1484817245 countsByYear W14848172452012 @default.
- W1484817245 crossrefType "journal-article" @default.
- W1484817245 hasAuthorship W1484817245A5020484711 @default.
- W1484817245 hasAuthorship W1484817245A5038281830 @default.
- W1484817245 hasBestOaLocation W14848172451 @default.
- W1484817245 hasConcept C116569031 @default.
- W1484817245 hasConcept C12554922 @default.
- W1484817245 hasConcept C170493617 @default.
- W1484817245 hasConcept C171250308 @default.
- W1484817245 hasConcept C185592680 @default.
- W1484817245 hasConcept C192562407 @default.
- W1484817245 hasConcept C2780841128 @default.
- W1484817245 hasConcept C40465926 @default.
- W1484817245 hasConcept C55493867 @default.
- W1484817245 hasConcept C86803240 @default.
- W1484817245 hasConceptScore W1484817245C116569031 @default.
- W1484817245 hasConceptScore W1484817245C12554922 @default.
- W1484817245 hasConceptScore W1484817245C170493617 @default.
- W1484817245 hasConceptScore W1484817245C171250308 @default.
- W1484817245 hasConceptScore W1484817245C185592680 @default.
- W1484817245 hasConceptScore W1484817245C192562407 @default.
- W1484817245 hasConceptScore W1484817245C2780841128 @default.
- W1484817245 hasConceptScore W1484817245C40465926 @default.
- W1484817245 hasConceptScore W1484817245C55493867 @default.
- W1484817245 hasConceptScore W1484817245C86803240 @default.
- W1484817245 hasIssue "5" @default.
- W1484817245 hasLocation W14848172451 @default.
- W1484817245 hasOpenAccess W1484817245 @default.
- W1484817245 hasPrimaryLocation W14848172451 @default.
- W1484817245 hasRelatedWork W1979805200 @default.
- W1484817245 hasRelatedWork W1980377213 @default.
- W1484817245 hasRelatedWork W2035164663 @default.
- W1484817245 hasRelatedWork W2411114012 @default.
- W1484817245 hasRelatedWork W2418180845 @default.
- W1484817245 hasRelatedWork W2739417245 @default.
- W1484817245 hasRelatedWork W2952244581 @default.
- W1484817245 hasRelatedWork W3037456415 @default.
- W1484817245 hasRelatedWork W4245315843 @default.
- W1484817245 hasRelatedWork W4290359253 @default.
- W1484817245 hasVolume "251" @default.
- W1484817245 isParatext "false" @default.
- W1484817245 isRetracted "false" @default.
- W1484817245 magId "1484817245" @default.
- W1484817245 workType "article" @default.