Matches in SemOpenAlex for { <https://semopenalex.org/work/W1484839986> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1484839986 endingPage "63" @default.
- W1484839986 startingPage "555" @default.
- W1484839986 abstract "Recently there was huge increase in using of 'herbal products'. These can be defined as plants, parts of plants or extracts from plants that are used for curing disease. However, Calophyllum species is a tropical plant and it has been used in traditional medicine, the limitation in safety and effectiveness information could lead to serious health problems. Providing information for communities by evaluating the phytochemical contents, antioxidant, antimicrobial and cytotoxic activities will improve the therapeutic values. Three main Calophyllum canum fractions (none - high polar) were tested to find out the phenolic, flavonoid, flavonol content, DPPH radical scavenging, reducing power and chelating iron ions. Also were tested against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Psedomonas aeruginosa, Candida albicans, and Cryptococcus neoformans. In addition, cytotoxic activity was assayed against lung cancer A549 cell line. The methanol fraction showed no bioactivity but achieved the highest amount of phenolic, flavonol and flavonoid contents, also it showed a significant result as antioxidant, reducing power and chelating agent. The n-hexane fraction achieved the minimum inhibitory concentration (MIC) value 12.5 μg. mL(-1) against B. cereus while the MIC value for DCM fraction was 25 μg. mL(-1). The DCM fraction was more active against S. aureus where the result was 50 μg. mL(-1) while the n-hexane fraction was 100 μg. mL(-1). The three main fractions have shown no activity against gram negative bacterial and fungal. The n-hexane and DCM fractions have shown cytotoxicity against lung cancer cell line; the 50% inhibition concentration (IC(50)) was 22 ± 2.64 and 32 ± 3.78 μg. mL(-1) respectively. The results were statistically significant (P < 0.05). Among the results, C. canum fractions proved to be effective against gram positive bacterial and anti-proliferation activity. Also it showed antioxidant activity as well. The results provided beneficial information for communities as well as can help to search for alternative drugs, and will contribute to establish safe and effective use of phytomedicines in the treatment of diseases." @default.
- W1484839986 created "2016-06-24" @default.
- W1484839986 creator A5008936484 @default.
- W1484839986 creator A5024796859 @default.
- W1484839986 creator A5028284421 @default.
- W1484839986 creator A5058506794 @default.
- W1484839986 creator A5070582146 @default.
- W1484839986 creator A5080172776 @default.
- W1484839986 creator A5084310113 @default.
- W1484839986 date "2012-07-01" @default.
- W1484839986 modified "2023-09-28" @default.
- W1484839986 title "The phytochemical content and antimicrobial activities of Malaysian Calophyllum canum (stem bark)." @default.
- W1484839986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22713941" @default.
- W1484839986 hasPublicationYear "2012" @default.
- W1484839986 type Work @default.
- W1484839986 sameAs 1484839986 @default.
- W1484839986 citedByCount "4" @default.
- W1484839986 countsByYear W14848399862014 @default.
- W1484839986 countsByYear W14848399862015 @default.
- W1484839986 countsByYear W14848399862017 @default.
- W1484839986 crossrefType "journal-article" @default.
- W1484839986 hasAuthorship W1484839986A5008936484 @default.
- W1484839986 hasAuthorship W1484839986A5024796859 @default.
- W1484839986 hasAuthorship W1484839986A5028284421 @default.
- W1484839986 hasAuthorship W1484839986A5058506794 @default.
- W1484839986 hasAuthorship W1484839986A5070582146 @default.
- W1484839986 hasAuthorship W1484839986A5080172776 @default.
- W1484839986 hasAuthorship W1484839986A5084310113 @default.
- W1484839986 hasConcept C176947019 @default.
- W1484839986 hasConcept C178790620 @default.
- W1484839986 hasConcept C185592680 @default.
- W1484839986 hasConcept C195475562 @default.
- W1484839986 hasConcept C2777118263 @default.
- W1484839986 hasConcept C2778004101 @default.
- W1484839986 hasConcept C2779054382 @default.
- W1484839986 hasConcept C2781401929 @default.
- W1484839986 hasConcept C31903555 @default.
- W1484839986 hasConcept C4937899 @default.
- W1484839986 hasConcept C523546767 @default.
- W1484839986 hasConcept C54355233 @default.
- W1484839986 hasConcept C55493867 @default.
- W1484839986 hasConcept C556039675 @default.
- W1484839986 hasConcept C71924100 @default.
- W1484839986 hasConcept C86803240 @default.
- W1484839986 hasConceptScore W1484839986C176947019 @default.
- W1484839986 hasConceptScore W1484839986C178790620 @default.
- W1484839986 hasConceptScore W1484839986C185592680 @default.
- W1484839986 hasConceptScore W1484839986C195475562 @default.
- W1484839986 hasConceptScore W1484839986C2777118263 @default.
- W1484839986 hasConceptScore W1484839986C2778004101 @default.
- W1484839986 hasConceptScore W1484839986C2779054382 @default.
- W1484839986 hasConceptScore W1484839986C2781401929 @default.
- W1484839986 hasConceptScore W1484839986C31903555 @default.
- W1484839986 hasConceptScore W1484839986C4937899 @default.
- W1484839986 hasConceptScore W1484839986C523546767 @default.
- W1484839986 hasConceptScore W1484839986C54355233 @default.
- W1484839986 hasConceptScore W1484839986C55493867 @default.
- W1484839986 hasConceptScore W1484839986C556039675 @default.
- W1484839986 hasConceptScore W1484839986C71924100 @default.
- W1484839986 hasConceptScore W1484839986C86803240 @default.
- W1484839986 hasIssue "3" @default.
- W1484839986 hasLocation W14848399861 @default.
- W1484839986 hasOpenAccess W1484839986 @default.
- W1484839986 hasPrimaryLocation W14848399861 @default.
- W1484839986 hasRelatedWork W1481676406 @default.
- W1484839986 hasRelatedWork W1985797884 @default.
- W1484839986 hasRelatedWork W2185954902 @default.
- W1484839986 hasRelatedWork W2336785067 @default.
- W1484839986 hasRelatedWork W2602420469 @default.
- W1484839986 hasRelatedWork W2987459451 @default.
- W1484839986 hasRelatedWork W3082576552 @default.
- W1484839986 hasRelatedWork W4206919479 @default.
- W1484839986 hasRelatedWork W2181681214 @default.
- W1484839986 hasRelatedWork W2186889101 @default.
- W1484839986 hasVolume "25" @default.
- W1484839986 isParatext "false" @default.
- W1484839986 isRetracted "false" @default.
- W1484839986 magId "1484839986" @default.
- W1484839986 workType "article" @default.