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• W1484981399 abstract "Acetylated amino sugars, normally used in the biosynthesis of cell walls and cell membranes, were found to play a role as corepressors for catabolite repression of the lac operon in Escherichia coli . This conclusion was derived from studies conducted on mutants of E. coli that were able to assimilate an exogenous source of N -acetylglucosamine (AcGN) but were unable to dissimilate or grow on this compound. At concentrations less than 10 −4 m , AcGN caused severe catabolite repression of β-galactosidase synthesis in cultures grown under either nonrepressed or partially repressed conditions. This repression occurred in the absence of any effect of AcGN on either the carbon and energy metabolism or the growth of the organism. In addition, this repression by AcGN occurred in a mutant strain that is constitutive for β-galactosidase production, demonstrating that the AcGN effect does not involve the uptake of inducer. This model for the corepressor system of catabolite repression is discussed in relation to the existing theories on repression of the lac operon." @default.
• W1484981399 created "2016-06-24" @default.
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• W1484981399 date "1969-03-01" @default.
• W1484981399 modified "2023-09-28" @default.
• W1484981399 title "Corepressor System for Catabolite Repression of the <i>lac</i> Operon in <i>Escherichia coli</i>" @default.
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• W1484981399 doi "https://doi.org/10.1128/jb.97.3.1083-1092.1969" @default.
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