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- W1484984825 abstract "Abstract Background: The purpose of the study was to develop a system of risk stratification, based on clinical and histological factors that would aid prediction of metastasis from cutaneous squamous cell carcinoma (SCC) of the head and neck. Method: The method used was a retrospective case control study comparing clinical and histological parameters of 78 patients who developed metastasis with 92 patients who did not develop metastasis over a 5‐year period. Results: The two ‘absolute’ (highest) risk factors for development of metastatic disease are poor histological differentiation and perineural/lymphovascular infiltration. The three ‘relative’ risk factors are moderate histological differentiation, diameter ≥20 mm and Clark level 5. Risk stratification: High‐risk lesions have either one of the absolute risk factors or all three of the relative risk factors with a predicted incidence of metastasis of 37%. Intermediate risk lesions have two of three relative risk factors and a predicted incidence of metastasis of 5%. Low‐risk lesions have one or none of the relative risk factors and a predicted incidence of meatstasis of 0.3%. Conclusion: Ongoing management of patients with histo‐pathologically proven invasive SCC of the head and neck should be based upon risk stratification for metastasis." @default.
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- W1484984825 date "2012-01-31" @default.
- W1484984825 modified "2023-10-18" @default.
- W1484984825 title "Risk stratification for metastasis from cutaneous squamous cell carcinoma of the head and neck" @default.
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- W1484984825 doi "https://doi.org/10.1111/j.1445-2197.2011.05994.x" @default.
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