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- W1484990799 abstract "Introduction: Cardiac resynchronization therapy (CRT) patients with improved functional mitral regurgitation (MR) have better clinical outcomes, though a significant proportion still have residual MR. We hypothesized that heart failure (HF) biomarkers (amino-terminal pro-B type natriuretic peptide [NT-proBNP, myocardial stretch], high-sensitivity troponin [hsTnI, myonecrosis], galectin 3 [gal-3, fibrosis] and soluble ST-2 [sST2, stress/fibrotic/remodelling]) may predict MR response after CRT. Methods: In 132 patients undergoing CRT, we measured peripheral venous levels of NT-proBNP, hsTnI, gal-3, and sST2 during device implantation. Patients were followed for two years. We measured Echo LV volumes, ejection fraction (EF), and MR grade at baseline and 6 months. MR was graded as no-trace (1), mild (2), moderate (3) or severe (4). MR improvement was defined as improvement of ≥1 grade by 6 months. Results: Baseline MR was no-trace in 27 (21%) patients, mild in 43 (33%) and moderate/severe in 62 (47%). Median NT-proBNP and sST2 levels were higher in patients with significant (grade 3 or 4) MR vs grade 1 or 2 MR (2671 vs 991 pg/mL, p Conclusion: Novel biomarkers of myonecrosis and fibrosis (hsTnI and gal-3) are associated with MR response after CRT, while markers of myocardial stretch and stress (NT-proBNP and sST2) are not. CRT patients whose MR did not improve by 6 months had worse 2-year survival. Predicting MR response with CRT can potentially influence clinical management; larger studies are therefore needed to confirm our findings." @default.
- W1484990799 created "2016-06-24" @default.
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- W1484990799 date "2014-11-25" @default.
- W1484990799 modified "2023-09-24" @default.
- W1484990799 title "Abstract 17390: Novel Heart Failure Biomarkers Predict Improvement of Mitral Regurgitation in Patients Receiving Cardiac Resynchronization Therapy_The BIOCRT Study" @default.
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