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• W1484992502 abstract "The constant emergence of new bacterial strains that resist the effectiveness of marketed antimicrobials has led to an urgent demand for and intensive research on new classes of compounds to combat bacterial infections. Antimicrobial peptoids comprise one group of potential candidates for antimicrobial drug development. The present study highlights a library of 22 cationic amphipathic peptoids designed to target bacteria. All the peptoids share an overall net charge of +4 and are 8 to 9 residues long; however, the hydrophobicity and charge distribution along the abiotic backbone varied, thus allowing an examination of the structure-activity relationship within the library. In addition, the toxicity profiles of all peptoids were assessed in human red blood cells (hRBCs) and HeLa cells, revealing the low toxicity exerted by the majority of the peptoids. The structural optimization also identified two peptoid candidates, 3 and 4, with high selectivity ratios of 4 to 32 and 8 to 64, respectively, and a concentration-dependent bactericidal mode of action against Gram-negative Escherichia coli." @default.
• W1484992502 created "2016-06-24" @default.
• W1484992502 creator A5018271056 @default.
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• W1484992502 date "2015-07-01" @default.
• W1484992502 modified "2023-10-09" @default.
• W1484992502 title "Structure-Activity Relationship Study of Novel Peptoids That Mimic the Structure of Antimicrobial Peptides" @default.
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• W1484992502 doi "https://doi.org/10.1128/aac.00237-15" @default.
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